Opportunities for Riboswitch Inhibition by Targeting Co-Transcriptional RNA Folding Events.

Christine Stephen, Danea Palmer, Tatiana V Mishanina

Abstract readReview

In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hierarchical analysis of RNA secondary structures with pseudoknots based on sections.PLoS computational biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christine StephenDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

Danea PalmerDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

Tatiana V MishaninaDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Mechanisms of transcription and co-transcriptional gene expression processes in bacteria and human mitochondriaR35GM142785 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tatiana Vladimirovna Mishanina · 2021 to 2026

$2.5M

Burroughs Wellcome Fund 1016945National Institute of Health 2016389National Science Foundation DGE-2038238NIGMS NIH HHS R35 GM142785

6 · The paper itself

Abstract

Antibiotic resistance is a critical global health concern, causing millions of prolonged bacterial infections every year and straining our healthcare systems. Novel antibiotic strategies are essential to combating this health crisis and bacterial non-coding RNAs are promising targets for new antibiotics. In particular, a class of bacterial non-coding RNAs called riboswitches has attracted significant interest as antibiotic targets. Riboswitches reside in the 5'-untranslated region of an mRNA transcript and tune gene expression levels

Indexed as

RiboswitchRNA FoldingAnti-Bacterial AgentsBacteriaGene Expression Regulation, BacterialLigandsNucleic Acid ConformationRNA, BacterialTranscription, GeneticAnti-Bacterial AgentsLigandsRiboswitchRNA, Bacterialantibioticsantisense oligonucleotidebacteriadrug targetriboswitchriboswitch inhibitorRNA foldingtranscriptiontranslation

Identifiers

PMID39408823

DOI10.3390/ijms251910495

PMCPMC11476745

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.