Evidence map›Paper›PMID 39408816›Full record

ReviewInternational journal of molecular sciences2024

Genetic Background of Medication-Related Osteonecrosis of the Jaw: Current Evidence and Future Perspectives.

Bence Bojtor, Bernadett Balla, Mihaly Vaszilko, Szofia Szentpeteri, Zsuzsanna Putz, Janos P Kosa, Peter Lakatos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Mesenchymal Stem Cells in Socket Healing and MRONJ.Orthodontics & craniofacial research · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bence BojtorDepartment of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.ORCID 0009-0004-5018-751X
Bernadett BallaHungarian Research Network SE-ENDOMOLPAT Research Group, 1085 Budapest, Hungary.
Mihaly VaszilkoDepartment of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, 1085 Budapest, Hungary.
Szofia SzentpeteriDepartment of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, 1085 Budapest, Hungary.
Zsuzsanna PutzDepartment of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Janos P KosaDepartment of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Peter LakatosDepartment of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.

Funding

Hungarian Research Network SE-ELKH ENDOMOLPATMinistry of Innovation and Technology 2020-4.1.1.-TKP2020-MOLORKIV
6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a rare side effect of antiresorptive drugs that significantly hinders the quality of life of affected patients. The disease develops in the presence of a combination of factors. Important pathogenetic factors include inflammation, inhibition of bone remodeling, or genetic predisposition. Since the first description of this rare side effect in 2003, a growing body of data has suggested a possible role for genetic factors in the disease. Several genes have been suggested to play an important role in the pathogenesis of MRONJ such as

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawGenetic Predisposition to DiseaseBone Density Conservation AgentsCytochrome P-450 CYP2C8HumansSirtuin 1Vascular Endothelial Growth Factor ABone Density Conservation AgentsCYP2C8 protein, humanCytochrome P-450 CYP2C8SIRT1 protein, humanSirtuin 1Vascular Endothelial Growth Factor AVEGFA protein, humangene expressiongenetic backgroundmedication-related osteonecrosis of the jawmicroRNAsingle nucleotide polymorphism

Identifiers

PMID39408816
PMCPMC11477157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.