Evidence map›Paper›PMID 39408773›Full record

ArticleInternational journal of molecular sciences2024

SHH Signaling as a Key Player in Endometrial Cancer: Unveiling the Correlation with Good Prognosis, Low Proliferation, and Anti-Tumor Immune Milieu.

V P Snijesh, Shivakumar Krishnamurthy, Vipul Bhardwaj, K M Punya, Ashitha S Niranjana Murthy, Mahmoud Almutadares, Wisam Tahir Habhab, Khalidah Khalid Nasser, Babajan Banaganapalli, Noor Ahmad Shaik and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

V P SnijeshDivision of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore 560034, Karnataka, India.ORCID 0000-0002-2215-9042
Shivakumar KrishnamurthyDivision of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore 560034, Karnataka, India.
Vipul BhardwajTsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0001-5509-8840
K M PunyaElectronics & Communication Engineering, Excel College of Technology, Namakkal 637303, Tamilnadu, India.
Ashitha S Niranjana MurthyDepartment of Psychiatry, National Institute of Mental Health And Neuro Sciences, Bangalore 560029, Karnataka, India.
Mahmoud AlmutadaresDepartment of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-1312-6409
Wisam Tahir HabhabDepartment of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Khalidah Khalid NasserPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Babajan BanaganapalliDepartment of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Noor Ahmad ShaikDepartment of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-8635-4947
Walaa F AlbaqamiDepartment of Science, Prince Sultan Military College of Health Sciences, Dhahran 31932, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial Cancer (EC) is one of the most common gynecological malignancies. Despite its prevalence, molecular pathways, such as the Sonic Hedgehog (SHH) pathway, have not been extensively studied in the context of EC. This study aims to explore the clinical implications of SHH expression in EC, potentially uncovering new insights into the disease's pathogenesis and offering valuable insights for therapeutic strategies in EC. We utilized data from The Cancer Genome Atlas (TCGA) to divide the dataset into '

Indexed as

Cell ProliferationEndometrial NeoplasmsGene Expression Regulation, NeoplasticHedgehog ProteinsSignal TransductionTumor MicroenvironmentBiomarkers, TumorFemaleHumansMiddle AgedPrognosisBiomarkers, TumorHedgehog ProteinsSHH protein, humanendometrial cancerimmune enrichmentprognostic biomarkersonic hedgehog pathwaytumor microenvironment

Identifiers

PMID39408773
PMCPMC11477284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.