Evidence map›Paper›PMID 39408749›Full record

ArticleInternational journal of molecular sciences2024

Estimation of Chloride Channel Residual Function and Assessment of Targeted Drugs Efficiency in the Presence of a Complex Allele [L467F;F508del] in the

Anna Efremova, Yuliya Melyanovskaya, Maria Krasnova, Anna Voronkova, Diana Mokrousova, Elena Zhekaite, Nataliya Bulatenko, Oleg Makhnach, Tatiana Bukharova, Sergei Kutsev and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna EfremovaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Yuliya MelyanovskayaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.ORCID 0000-0002-8814-5532
Maria KrasnovaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Anna VoronkovaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Diana MokrousovaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Elena ZhekaiteResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Nataliya BulatenkoResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Oleg MakhnachResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Tatiana BukharovaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.ORCID 0000-0003-0481-256X
Sergei KutsevResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Dmitry GoldshteinResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.
Elena KondratyevaResearch Centre for Medical Genetics, Moskvorechye Str. 1, 115522 Moscow, Russia.ORCID 0000-0001-6395-0407

Funding

Russian Science Foundation grant No 22-15-00473, "Investigation of the effect of complex alleles of the CFTR gene on the functional activity of the chloride channel for personalized selection of targeted therapy for cystic fibrosis"
6 · The paper itself

Abstract

Complex alleles of the

Indexed as

AllelesAminophenolsBenzodioxolesCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorGenotypeQuinolonesAdolescentAdultAminopyridinesChildChild, PreschoolChloride Channel AgonistsChloride ChannelsDrug CombinationsFemaleAminophenolsAminopyridinesBenzodioxolesCFTR protein, humanChloride Channel AgonistsChloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorDrug CombinationselexacaftorIndolesivacaftorlumacaftorPyrazolesPyridinesPyrrolidinesQuinolonestezacaftorCFTR modulatorscomplex allele [L467Fcystic fibrosis (CF)F508del]therapy

Identifiers

PMID39408749
PMCPMC11476812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.