Evidence map›Paper›PMID 39408697›Full record

ArticleInternational journal of molecular sciences2024

Transcriptome Profiling Associated with

Faisal Alhosani, Burcu Yener Ilce, Reem Sami Alhamidi, Poorna Manasa Bhamidimarri, Alaa Mohamed Hamad, Noura Alkhayyal, Axel Künstner, Cyrus Khandanpour, Hauke Busch, Basel Al-Ramadi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Faisal AlhosaniResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0000-0002-3553-7217
Burcu Yener IlceResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0009-0009-2068-1089
Reem Sami AlhamidiResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0009-0006-2893-2872
Poorna Manasa BhamidimarriResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Alaa Mohamed HamadResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0009-0006-3196-8956
Noura AlkhayyalOncology Unit, University Hospital Sharjah, Sharjah P.O. Box 72772, United Arab Emirates.
Axel KünstnerMedical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.ORCID 0000-0003-0692-2105
Cyrus KhandanpourDepartment of Hematology and Oncology, University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0003-4655-6269
Hauke BuschMedical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.ORCID 0000-0003-4763-4521
Basel Al-RamadiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0002-1657-1938
Kadria SayedDepartment of Pathology and Laboratory Medicine, American Hospital Dubai, Dubai P.O. Box 3050, United Arab Emirates.
Ali AlFazariMediclinic Welcare Hospital, Dubai P.O. Box 31500, United Arab Emirates.
Riyad BendardafOncology Unit, University Hospital Sharjah, Sharjah P.O. Box 72772, United Arab Emirates.
Rifat HamoudiResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0000-0002-1402-0868

Funding

ASPIRE Precision Medicine Research Institute grant VRI-20-10
6 · The paper itself

Abstract

The immune system plays a critical role in inflammation by initiating responses to infections or tissue damage. The nuclear factor-κB (NF-κB) pathway plays a key role in inflammation and innate immunity, as well as other cellular activities. Dysregulation of this well-choreographed pathway has been implicated in various diseases, including cancer. CARD11 is a key molecule in the BCL10-MALT1 complex, which is involved in transducing the signal downstream of the NF-κB pathway. This study aims to elucidate how

Indexed as

CARD Signaling Adaptor ProteinsColorectal NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticNF-kappa BTumor MicroenvironmentCell Line, TumorGuanylate CyclaseHCT116 CellsHT29 CellsHumansSignal TransductionTranscriptomeCARD11 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseNF-kappa BCARD11colorectal cancerGSEANF-κB pathwaytumor immune microenvironment

Identifiers

PMID39408697
PMCPMC11476988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.