Evidence map›Paper›PMID 39408667›Full record

ArticleInternational journal of molecular sciences2024

Effect of Simulated Cosmic Radiation on Cytomegalovirus Reactivation and Lytic Replication.

Satish K Mehta, Douglass M Diak, Sara Bustos-Lopez, Mayra Nelman-Gonzalez, Xi Chen, Ianik Plante, Stephen J Stray, Ritesh Tandon, Brian E Crucian

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Satish K MehtaJES Tech, NASA, Johnson Space Center, Houston, TX 77058, USA.ORCID 0000-0003-4198-3261
Douglass M DiakAegis Aerospace, Inc., Houston, TX 77598, USA.
Sara Bustos-LopezDepartment of Health and Human Performance, University of Houston, Houston, TX 77004, USA.
Mayra Nelman-GonzalezKBR, Houston, TX 77002, USA.
Xi ChenKBR, Houston, TX 77002, USA.
Ianik PlanteKBR, Houston, TX 77002, USA.ORCID 0009-0001-9189-3654
Stephen J StrayDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Ritesh TandonDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Brian E CrucianNASA, Johnson Space Center, Houston, TX 77058, USA.

Funding

NASA 80NSSC19K1603
6 · The paper itself

Abstract

Human exploration of the solar system will expose crew members to galactic cosmic radiation (GCR), with a potential for adverse health effects. GCR particles (protons and ions) move at nearly the speed of light and easily penetrate space station walls, as well as the human body. Previously, we have shown reactivation of latent herpesviruses, including herpes simplex virus, Varicella zoster virus, Epstein-Barr virus, and cytomegalovirus (CMV), during stays at the International Space Station. Given the prevalence of latent CMV and the known propensity of space radiation to cause alterations in many cellular processes, we undertook this study to understand the role of GCR in reactivating latent CMV. Latently infected Kasumi cells with CMV were irradiated with

Indexed as

Cosmic RadiationCytomegalovirusVirus ActivationVirus ReplicationCell LineCytomegalovirus InfectionsGamma RaysGenome, ViralHumansVirus Latencycytomegalovirusgalactic cosmic radiationherpes viral reactivationradiationspaceflight

Identifiers

PMID39408667
PMCPMC11477029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.