Evidence map›Paper›PMID 39408638›Full record

ArticleInternational journal of molecular sciences2024

Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the

Sojin Y Wass, Han Sun, Gregory Tchou, Nana Liu, David R Van Wagoner, Mina K Chung, John Barnard, Jonathan D Smith

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sojin Y WassDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-9354-0011
Han SunDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-9164-5282
Gregory TchouDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.
Nana LiuDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-5010-599X
David R Van WagonerDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-8250-9828
Mina K ChungDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.
John BarnardDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0003-2403-8268
Jonathan D SmithDepartments of Cardiovascular & Metabolic Sciences, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-0415-386X

Funding

Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF ProgressionsP01HL158502 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Robert Alden Koeth · 2022 to 2026
$16.9M
Functional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1M
American Heart Association 18SFRN34110067NHLBI NIH HHS P01 HL158502NIH HHS 1P01HL158502-03A1NIH HHS 2R01HL111314-04A1
6 · The paper itself

Abstract

Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus on gene expression at the transcript isoform level in human left atria and to gain insight into potential causal variants. Bulk RNA sequencing was analyzed to identify myozenin 1 (

Indexed as

Atrial FibrillationGenetic Predisposition to DiseasePolymorphism, Single NucleotideGenome-Wide Association StudyHumansLinkage DisequilibriumMaleMicrofilament ProteinsMuscle ProteinsMyocytes, CardiacProtein IsoformsRNA, Long NoncodingTranscriptomeMicrofilament ProteinsMuscle ProteinsProtein IsoformsRNA, Long Noncodingatrial fibrillationeQTLGWASMYOZ1SNYPO2L

Identifiers

PMID39408638
PMCPMC11477451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.