Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.ORCID 0000-0003-2723-9217
Yong-Seok SongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Mitra FarnoodianDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Samay InampudiDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Barbara HannaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Shoujian WangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Soesiawati R DarjatmokoDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
VEGF Antagonism and Resistance to Neovascular AMDR01EY030076 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2020 to 2023
$1.5M
Bcl-2, Subretinal Scar Formation and Neovascular AMDR21EY034646 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2023 to 2023
$428k
Carl Marshall Reeves & Mildred Reeves Foundation Research Support for Macular DegenerationNCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS P30 EY016665, EY034646, EY030076NEI NIH HHS R01 EY030076NEI NIH HHS R21 EY034646Pat and Jay Smith AMD Innovation FundResearch to Prevent Blindness Unrestricted Award to the Department of Ophthalmology and Visual SciencesRetina Research Foundation Endoument Found
6 · The paper itself
Abstract
In the aging population, choroidal vessels grow through the Bruch's membrane, resulting in a loss of central vision due to choroidal neovascularization (CNV). During active neovascularization, CNV is associated with inappropriate levels of apoptosis in multiple cell types, including choroidal endothelial cells (ChECs). Bim is a pro-apoptotic member of the Bcl-2 family. It is essential for cell apoptosis due to exposure to drugs such as dexamethasone or decreased pro-survival factors, including vascular endothelial growth factor (VEGF). To better elucidate the cell autonomous contribution of Bim expression in the integrity and neovascularization of the choroidal vasculature, we isolated ChECs from wild-type and Bim-deficient (Bim
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Bim Expression Influences Choroidal Endothelial Cell Characteristics and Their Response to Therapeutic Intervention. · full record | OpenQuestion