Evidence map›Paper›PMID 39408325›Full record

Trial reportNutrients2024

Comparative Effectiveness of Ascorbic Acid vs. Calcium Ascorbate Ingestion on Pharmacokinetic Profiles and Immune Biomarkers in Healthy Adults: A Preliminary Study.

Broderick Dickerson, Drew E Gonzalez, Ryan Sowinski, Dante Xing, Megan Leonard, Jacob Kendra, Victoria Jenkins, Siddharth Gopalakrishnan, Choongsung Yoo, Joungbo Ko and 6 more

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Broderick DickersonExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Drew E GonzalezExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-7279-4968
Ryan SowinskiExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-3885-4100
Dante XingExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0008-4670-8094
Megan LeonardExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-4209-3885
Jacob KendraExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0002-9940-8497
Victoria JenkinsExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2348-5114
Siddharth GopalakrishnanExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Choongsung YooExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Joungbo KoExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Syamkumar Sivasankara PillaiVegetable and Fruit Improvement Center, Department of Horticulture, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9187-703X
Jigna R BhamoreVegetable and Fruit Improvement Center, Department of Horticulture, Texas A&M University, College Station, TX 77843, USA.
Bhimanagouda S PatilVegetable and Fruit Improvement Center, Department of Horticulture, Texas A&M University, College Station, TX 77843, USA.
Gus A WrightFlow Cytometry Facility, Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, USA.
Christopher J RasmussenExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.
Richard B KreiderExercise & Sport Nutrition Lab, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-3906-1658

Funding

The Bountiful Co. (Ronkonkoma, NY, USA) NTBY: 0001
6 · The paper itself

Abstract

backgroundPrevious trials have displayed augmented intracellular vitamin C concentrations in the leukocytes at 24 h after acute supplementation with 1000 mg calcium ascorbate (CA), compared to ascorbic acid (AA).

objectiveThe primary objective was to evaluate comparative leukocyte vitamin C accumulation kinetics over 32 h following acute 250 mg or 500 mg doses from the two sources. Secondary objectives were to evaluate neutrophil phagocytic function and lymphocyte differentiation between the two sources of vitamin C.

methodsNinety-three healthy females (250 mg,

resultsThere were no significant differences in the primary or secondary outcomes between the two treatments in the 250 mg low-dose study. Conversely, there was evidence that ingestion of 500 mg of CA increased DHA in plasma, increased neutrophil functionality during the first 8 h of the PK study, promoted increased natural killer cells, and altered weight-adjusted PK profiles, suggesting greater volume distribution and clearance from the blood.

conclusionsThese findings indicate that 500 mg of CA may promote some immune benefits compared to 500 mg of AA ingestion.

Indexed as

Ascorbic AcidBiomarkersCross-Over StudiesDietary SupplementsNeutrophilsAdultDouble-Blind MethodFemaleHealthy VolunteersHumansMalePhagocytosisYoung AdultAscorbic AcidBiomarkersbioavailabilitynutrient absorptionvitamin supplementation

Identifiers

PMID39408325
PMCPMC11479081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.