Evidence map›Paper›PMID 39408192›Full record

ArticleNutrients2024

Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency: Findings from the SarcoPhAge Cohort.

Aurélie Ladang, Anne-Sophie Gendebien, Stéphanie Kovacs, Céline Demonceau, Charlotte Beaudart, Stéphanie Peeters, Majed S Alokail, Nasser M Al-Daghri, Caroline Le Goff, Jean-Yves Reginster and 2 more

Abstract read
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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aurélie LadangDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-5316-3108
Anne-Sophie GendebienDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.
Stéphanie KovacsDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.
Céline DemonceauResearch Unit in Public Health, Epidemiology and Health Economics, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-7089-6605
Charlotte BeaudartClinical Pharmacology and Toxicology Research Unit (URPC), NARILIS, Department of Biomedical Sciences, University of Namur, 5000 Namur, Belgium.
Stéphanie PeetersDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.
Majed S AlokailProtein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Nasser M Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5472-1725
Caroline Le GoffDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-7816-3705
Jean-Yves ReginsterProtein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-6290-752X
Olivier BruyereResearch Unit in Public Health, Epidemiology and Health Economics, University of Liège, 4000 Liège, Belgium.ORCID 0000-0003-4269-9393
Etienne CavalierDepartment of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.

Funding

King Saud University Distinguished Scientists Fellowship Programme of the King Saud University
6 · The paper itself

Abstract

backgroundThe vitamin D metabolite ratio (VMR) has recently been identified as a potentially better indicator of vitamin D deficiency than 25-hydroxyvitamin D (25(OH)D) alone. This study aims to validate these findings by demonstrating that VMR is more strongly correlated with parathyroid hormone (PTH) levels than 25(OH)D and 24,25-dihydroxyvitamin D (24,25(OH)

methodsThe SarcoPhAge cohort is a Belgian cohort of community-dwelling older adults. Levels of 25(OH)D and 24,25(OH)

resultsA total of 35 individuals (17.2%) had 25(OH)D < 20 ng/mL, 40 individuals (19.6%) had 24,25(OH)

conclusionsThis study confirms that VMR is an efficient biomarker for assessing functional vitamin D deficiency.

Indexed as

BiomarkersParathyroid HormoneVitamin DVitamin D DeficiencyAgedAged, 80 and overBelgiumChromatography, LiquidCohort StudiesFemaleHumansMaleTandem Mass Spectrometry24,25-dihydroxyvitamin D25-hydroxyvitamin DBiomarkersParathyroid HormoneVitamin Dfunctional vitamin D deficiencymortality predictionparathyroid hormone (PTH)vitamin D metabolite ratio (VMR)

Identifiers

PMID39408192
PMCPMC11478400

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.