Evidence map›Paper›PMID 39408044›Full record

ArticleJournal of clinical medicine2024

Elevated Circulating Levels of Gut Microbe-Derived Trimethylamine

Karen J Ho, Lutfiyya N Muhammad, Linh Ngo Khanh, Xinmin S Li, Mary Carns, Kathleen Aren, Seok-Jo Kim, Priyanka Verma, Stanley L Hazen, John Varga

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karen J HoDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-7514-8953
Lutfiyya N MuhammadDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-8655-1484
Linh Ngo KhanhDepartment of Cardiovascular Surgery, Houston Methodist Hospital, Houston, TX 77030, USA.
Xinmin S LiDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0003-4946-4271
Mary CarnsDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-5063-156X
Kathleen ArenDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-4770-2643
Seok-Jo KimInstitute of Basic Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Priyanka VermaDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Stanley L HazenDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
John VargaDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Funding

Gut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8M
Resource CoreP30AR072579 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Leena Sharma · 2017 to 2026
$8.3M
Targeting the Meta-organismal Butyrate Pathway to Prevent Arterial Restenosis after Vascular SurgeryR01HL153306 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HO, KAREN J. · 2021 to 2025
$2.8M
COCOA PAD II: Effect of Cocoa Flavanols on the Gut Microbiome and Functional PerformanceR21AG081706 · NIA · UNIVERSITY OF CHICAGO · PI HO, KAREN J., POLONSKY, TAMAR S. · 2023 to 2023
$487k
Epigenetic regulation of the Klotho / Miz 1 axis in smoking-induced emphysema.R21AG060211 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, SEOK-JO, LIU, JING · 2019 to 2020
$407k
Metaorganismal TMAO pathway driving scleroderma pathogenesis: novel gene-environment interaction paradigm and therapeutic targetR33AR076821 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VARGA, JOHN · 2022 to 2022
$341k
Microbe-Related Modulation of Neointimal Hyperplasia after Arterial InjuryR03HL146880 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HO, KAREN J. · 2019 to 2020
$158k
NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL153306NHLBI NIH HHS R03 HL146880NIAMS NIH HHS P30 AR072579NIAMS NIH HHS R33 AR076821NIA NIH HHS R21 AG060211NIA NIH HHS R21 AG081706NIH (multiple institutes) R33AR076821 (to JV, KH, and LM), R03HL146880, R21AG081706, and R01HL153306 (to KH), R21AG060211 (to SK), and R01HL103866 (to SH).
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

case-control studiescholinecluster analysisgamma-butyrobetainegastrointestinal microbiomesclerodermasclerosissystemictrimethylamine N-oxide

Identifiers

PMID39408044
PMCPMC11477889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.