ReviewJournal of clinical medicine2024
Left Ventricular Non-Compaction: Evolving Concepts.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Atrial fibrillation in patients with left ventricular non-compaction: incidence and associations with stroke, heart failure, and mortality.Cardiovascular research · 2026Observational
- Rethinking Left Ventricular Noncompaction and Excessive Left Ventricular Trabeculation: Development, Genetics, and a Proposed Conceptual Framework.Journal of clinical medicine · 2026Review
- Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.Heart failure reviews · 2026Review
- Reversible left ventricular trabecular remodeling after bariatric surgery in obesity: a prospective cohort study using quantitative cardiac MRI.Quantitative imaging in medicine and surgery · 2026Article
- Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.Heart failure reviews · 2026Review
- Isolated right ventricular non-compaction in a post-MI elderly patient: a diagnostic blind spot in geriatric cardiology.Journal of geriatric cardiology : JGC · 2026Article
- How should we interpret excessive left ventricular trabeculation? Update on controversies from the cardiac imaging perspective.Insights into imaging · 2026Article
- Surgical outcomes and follow-up analysis of valvular heart disease combined with left ventricular excessive trabeculation: a retrospective propensity score matching study.Journal of cardiothoracic surgery · 2026Article
- The spongy heart paradox: balancing bleeding and clotting risk in left ventricular noncompaction cardiomyopathy.Heart failure reviews · 2026Review
- An infant case of double-chambered left ventricle with extensive non-compaction revealed by intraoperative endoscopy.Journal of cardiology cases · 2026Article
- Molecular Pathology of Cardiomyopathies: Bridging Morphology, Genomics, and Clinical Phenotypes.Current issues in molecular biology · 2026Review
- De Novo ACTN2 Variant in a Chinese Neonate With Left Ventricular Non-Compaction and Metabolic Disturbances: A Rare Case Report.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Left-ventricular Non-compaction Cardiomyopathy Presenting With Atrial Flutter With Rapid Ventricular Response.Journal of community hospital internal medicine perspectives · 2026Article
- A concise guide of contemporary cardiovascular imaging practices to differentiate athlete's heart in the gray zone.Heart failure reviews · 2025Review
- Left Ventricular Non-Compaction Cardiomyopathy: A Review of the Pathophysiology, Epidemiology, Diagnosis, Genetics, and Clinical Management.Journal of personalized medicine · 2025Review
- Excessive left ventricular trabeculations mimicking a thrombus.European heart journal. Case reports · 2025Article
- UtilizingJournal of developmental biology · 2025Review
- Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular non-compaction (LVNC) is a rare heart muscle disease defined by the presence of prominent left ventricular trabeculation, deep intertrabecular recesses, and a thin compact layer. Several hypotheses have been proposed regarding its pathogenesis, with the most recently accepted one being that compact layer and trabeculated layers develop independently according to an "allometric growth". The current gold-standard diagnostic criteria (in particular, the Petersen index non-compaction/compaction ratio > 2.3) reflect an excess of myocardial trabeculation, which is not a specific morpho-functional feature of LVNC cardiomyopathy but merely a "phenotypic trait", even described in association with other myocardial disease and over-loading conditions. Accordingly, the European Society of Cardiology (ESC) guidelines have definitively abolished the term 'LVNC cardiomyopathy'. Recently, evolving perspectives led to the restoration of LVNC cardiomyopathy by distinguishing "hypertrabeculation phenotype" and "non-compaction phenotype". It has been proposed that the disease-specific pathophysiologic mechanism is a congenitally underdevelopment of the compact layer accounting for an impairment of the left ventricular systolic function. Future prospective research should focus on the clinical and prognostic relevance of compact layer thinning rather than excessive trabeculation, which could significantly influence the management of patients with LVNC. The review aims to update current knowledge on the pathogenesis, genetics, and diagnostic criteria of LVNC, offering modern insights for future perspectives.
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