Evidence map›Paper›PMID 39407710›Full record

ReviewMolecules (Basel, Switzerland)2024

Inclusion Complexation of Remdesivir with Cyclodextrins: A Comprehensive Review on Combating Coronavirus Resistance-Current State and Future Perspectives.

Arumugam Anitha, Rajaram Rajamohan, Moorthiraman Murugan, Jeong Hyun Seo

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arumugam AnithaPG and Research Department of Chemistry, Government Arts College, Chidambaram 608 102, Tamil Nadu, India.
Rajaram RajamohanSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.ORCID 0000-0002-6141-9425
Moorthiraman MuruganDepartment of Chemistry, IFET College of Engineering, Villupuram 605 108, Tamil Nadu, India.
Jeong Hyun SeoSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.ORCID 0000-0001-6970-4653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclodextrin (CD) derivatives have gained significant attention in biomedical applications due to their remarkable biocompatibility, unique inclusion capabilities, and potential for functionalization. This review focuses on recent advancements in CD-based assemblies, specifically their role in improving drug delivery, emphasizing remdesivir (RMD). The review introduces CD materials and their versatile applications in self-assembly and supramolecular assembly. CD materials offer immense potential for designing drug delivery systems with enhanced activity. Their inherent inclusion capabilities enable the encapsulation of diverse therapeutic agents, including RMD, resulting in improved solubility, stability, and bioavailability. The recent advances in CD-based assemblies, focusing on their integration with RMD have been concentrated here. Various strategies for constructing these assemblies are discussed, including physical encapsulation, covalent conjugation, and surface functionalization techniques. Furthermore, exploring future directions in these fields has also been provided. Ongoing research efforts are directed toward developing novel CD derivatives with enhanced properties, such as increased encapsulation efficiency and improved release kinetics. Moreover, the integration of CD-based assemblies with advanced technologies such as nanomedicine and gene therapy holds tremendous promise for personalized medicine and precision therapeutics.

Indexed as

Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19 Drug TreatmentCyclodextrinsSARS-CoV-2COVID-19Drug Delivery SystemsHumansAdenosine MonophosphateAlanineAntiviral AgentsCyclodextrinsremdesivirCOVID-19cyclodextrinsinclusion complexesremdesivir

Identifiers

PMID39407710
PMCPMC11477750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.