Design, Synthesis, and Antimicrobial Evaluation of New Thiopyrimidine-Benzenesulfonamide Compounds.

Abdalrahman Khalifa, Manal M Anwar, Walaa A Alshareef, Eman A El-Gebaly, Samia A Elseginy, Sameh H Abdelwahed

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-RSC advances · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abdalrahman KhalifaDepartment of Chemistry, Prairie View A&M University, Prairie View, TX 77446, USA.

Manal M AnwarDepartment of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo P.O. Box 12622, Egypt.

Walaa A AlshareefMicrobiology and Immunology Department, Faculty of Pharmacy, O6U, Giza P.O. Box 12585, Egypt.ORCID 0000-0003-3487-9044

Eman A El-GebalyMicrobiology and Immunology Department, Faculty of Pharmacy, O6U, Giza P.O. Box 12585, Egypt.ORCID 0000-0002-5913-4092

Samia A ElseginyGreen Chemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo P.O. Box 12622, Egypt.ORCID 0000-0002-0040-0288

Sameh H AbdelwahedDepartment of Chemistry, Prairie View A&M University, Prairie View, TX 77446, USA.ORCID 0000-0002-3445-4065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial infection poses a serious threat to human life due to the rapidly growing resistance of bacteria to antibacterial drugs, which is a significant public health issue. This study was focused on the design and synthesis of a new series of 25 analogues bearing a 5-cyano-6-oxo-4-substituted phenyl-1,6-dihydropyrimidine scaffold hybridized with different substituted benzenesulfonamides through the thioacetamide linker

Indexed as

BenzenesulfonamidesBiofilmsDrug DesignMicrobial Sensitivity TestsPyrimidinesSulfonamidesAnti-Bacterial AgentsAnti-Infective AgentsBacteriaHumansMolecular StructurePseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsBenzenesulfonamidesPyrimidinesSulfonamidesantimicrobial activityanti-virulence activitybactericidal activitybenzenesulfonamidesin silico ADMETthiopyrimidine

Identifiers

PMID39407706

DOI10.3390/molecules29194778

PMCPMC11477697

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.