ArticleMolecules (Basel, Switzerland)2024
Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties.
Arina V Murashkina, Andrei V Bogdanov, Alexandra D Voloshina, Anna P Lyubina, Alexandr V Samorodov, Alexander Y Mitrofanov, Irina P Beletskaya, Elena A Smolyarchuk, Kseniya A Zavadich, Zulfiya A Valiullina and 3 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Arina V MurashkinaDepartment of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-4288-8912 Andrei V BogdanovA. M. Butlerov Institute of Chemistry, Kazan Federal University, 420008 Kazan, Russia.
Alexandra D VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russia.
Anna P LyubinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russia.ORCID 0000-0002-2816-8142 Alexandr V SamorodovDepartment of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.ORCID 0000-0001-9302-499X Alexander Y MitrofanovDepartment of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0003-3141-3599 Irina P BeletskayaDepartment of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-9705-1434 Elena A SmolyarchukThe A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 119571 Moscow, Russia.
Kseniya A ZavadichThe A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 119571 Moscow, Russia.ORCID 0000-0002-4792-7132 Zulfiya A ValiullinaDepartment of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.ORCID 0009-0006-9107-0435 Vladislav I KorunasDepartment of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.ORCID 0000-0001-6809-5892 Irina D KrylovaDepartment of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.
Funding
Russian Science Foundation 23-25-00144
6 · The paper itselfAbstract
An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates. It was found that various aryl-substituted and N-functionalized isatins with the formation of appropriate products with high yields and stereoselectivity when using
Indexed as
Antineoplastic AgentsIsatinOrganophosphonatesOxindolesPlatelet Aggregation InhibitorsAdolescentAnticoagulantsCatalysisCell DeathCell Line, TumorHumansInhibitory Concentration 50MaleYoung AdultAnticoagulantsAntineoplastic AgentsIsatinOrganophosphonatesOxindolesPlatelet Aggregation Inhibitorsanticoagulantscytotoxicityisatinphosphonatesspiro compoundsstereoselectivity
Identifiers
PMID39407692
PMCPMC11477635
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