Application of the Wittig Rearrangement of

R Alan Aitken, Francesca K Cooper, Andrew D Harper, Ryan A Inwood, Elizabeth A Saab, Ewan J Soutar

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R Alan AitkenEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.ORCID 0000-0001-6959-5311

Francesca K CooperEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.

Andrew D HarperEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.

Ryan A InwoodEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.

Elizabeth A SaabEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.

Ewan J SoutarEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St. Andrews KY16 9ST, Fife, UK.

Funding

Engineering and Physical Sciences Research Council EP/L016419/1Engineering and Physical Sciences Research Council EP/L505079/1

6 · The paper itself

Abstract

Application of the [1,2]-Wittig rearrangement and cyclisation approach to 3-arylphthalides has been evaluated for the synthesis of three bioactive natural products. While this is successful in the case of crycolide, providing the second synthesis of this compound, the more sterically demanding targets isopestacin and cryphonectric acid prove not to be amenable to this approach, with the 2,6-disubstituted aryl groups causing the failure of the rearrangement and alkylation steps, respectively. Direct oxidation of the substituted benzhydrols resulting from [1,2]-Wittig rearrangement using MnO

Indexed as

[1,2]-Wittig rearrangement3-aryl-3-hydroxyisoindolinones3-arylphthalidesanticancer agentsnatural products

Identifiers

PMID39407650

DOI10.3390/molecules29194722

PMCPMC11478121

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.