ArticleMolecules (Basel, Switzerland)2024
Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired
Han Zhang, Qianqian Shen, Zhu Hu, Pei-Qian Wu, Yi Chen, Jin-Xin Zhao, Jian-Min Yue
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Han ZhangSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
Qianqian ShenState Key Laboratory of Chemical Biology, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.ORCID 0000-0003-1849-681X Zhu HuState Key Laboratory of Drug Research, Ethnomedicine and Biofunctional Molecule Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Pei-Qian WuState Key Laboratory of Drug Research, Ethnomedicine and Biofunctional Molecule Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Yi ChenState Key Laboratory of Chemical Biology, Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Jin-Xin ZhaoState Key Laboratory of Drug Research, Ethnomedicine and Biofunctional Molecule Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Jian-Min YueSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
Funding
National Natural Science Foundation of China 22237007, T2192972Shandong Laboratory Program SYS202205Shanghai Institute of Materia Medica SIMM0120231002Youth Innovation Promotion Association 2022282
6 · The paper itselfAbstract
Drawing inspiration from the structural resemblance between a natural product
Indexed as
ApoptosisBiological ProductsDrug DesignHistone Deacetylase InhibitorsMolecular Docking SimulationPyrrolesAntineoplastic AgentsCell Line, TumorHistone Deacetylase 1HumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsBiological ProductsHDAC1 protein, humanHistone Deacetylase 1Histone Deacetylase InhibitorsPyrrolesanti-cancer activityHDAC inhibitorsmolecular dockingmolecular dynamics simulationnatural productspyrrole derivatives
Identifiers
PMID39407581
PMCPMC11477621
What OpenQuestion holds
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LicenceCC BY
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