Evidence map›Paper›PMID 39407467›Full record

ArticleMolecules (Basel, Switzerland)2024

Quaternized Curcumin Derivative-Synthesis, Physicochemical Characteristics, and Photocytotoxicity, Including Antibacterial Activity after Irradiation with Blue Light.

Pawel Bakun, Marcin Wysocki, Magdalena Stachowiak, Marika Musielak, Jolanta Dlugaszewska, Dariusz T Mlynarczyk, Lukasz Sobotta, Wiktoria M Suchorska, Tomasz Goslinski

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. In Vitro Evaluation ofInternational journal of molecular sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pawel BakunChair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0002-0831-2856
Marcin WysockiDoctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.ORCID 0000-0003-3585-2716
Magdalena StachowiakChair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Marika MusielakDoctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.ORCID 0000-0002-8187-2446
Jolanta DlugaszewskaChair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0002-2192-3715
Dariusz T MlynarczykChair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0003-3583-0752
Lukasz SobottaChair and Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0002-5062-4503
Wiktoria M SuchorskaDepartment of Electroradiology, Poznan University of Medical Sciences, Garbary 15, 61-866 Poznan, Poland.
Tomasz GoslinskiChair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0001-5705-5414

Funding

Poznan University of Medical Sciences SDUM-DGB 01/05/22Poznan University of Medical Sciences SDUM-MGB 01/04/23
6 · The paper itself

Abstract

Over the past few years, numerous bacterial strains have become resistant to selected drugs from various therapeutic groups. A potential tool in the fight against these strains is antimicrobial photodynamic therapy (APDT). APDT acts in a non-specific manner by generating reactive oxygen species and radicals, thereby inducing multidimensional intracellular effects. Importantly, the chance that bacteria will develop defense mechanisms against APDT is considered to be low. In our research, we performed the synthesis and physicochemical characterization of curcumin derivatives enriched with morpholine motifs. The obtained compounds were assessed regarding photostability, singlet oxygen generation, aggregation, and acute toxicity toward prokaryotic

Indexed as

Anti-Bacterial AgentsCurcuminLightAliivibrio fischeriBacteriaBlue LightCell SurvivalHumansMicrobial Sensitivity TestsPhotochemotherapyPhotosensitizing AgentsPseudomonas aeruginosaSinglet OxygenAnti-Bacterial AgentsCurcuminPhotosensitizing AgentsSinglet Oxygencurcumin derivativesMicrotoxmorpholineMTTPACTtoxicity

Identifiers

PMID39407467
PMCPMC11478334

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.