Evidence map›Paper›PMID 39407336›Full record

SynthesisSystematic reviews2024

Liver and renal biochemical profiles of people with sickle cell disease in Africa: a systematic review and meta-analysis of case-control studies.

Silvia Awor, Felix Bongomin, Mark Mohan Kaggwa, Francis Pebalo Pebolo, Jackie Epila, Geoffrey Maxwell Malinga, Christine Oryema, Proscovia Nnamuyomba, Benard Abola, Acaye Ongwech and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvia AworDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Gulu University, P. O. Box 166, Gulu, Uganda. s.awor@gu.ac.ug.ORCID 0000-0002-9701-2264
Felix BongominDepartment of Medical Microbiology & Immunology, Faculty of Medicine, Gulu University, P.O. Box 166, Gulu, Uganda.
Mark Mohan KaggwaDepartment of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Canada.
Francis Pebalo PeboloDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Gulu University, P. O. Box 166, Gulu, Uganda.
Jackie EpilaFaculty of Education, Lira University, P.O. Box 1035, Lira, Uganda.
Geoffrey Maxwell MalingaDepartment of Biology, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
Christine OryemaDepartment of Biology, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
Proscovia NnamuyombaDepartment of Chemistry, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
Benard AbolaDepartment of Mathematics, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
Acaye OngwechDepartment of Chemistry, Faculty of Science, Gulu University, P.O. Box 166, Gulu, Uganda.
David MusokeDepartment of Pharmacology & Therapeutics, Faculty of Medicine, Gulu University, P.O. Box 166, Gulu, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSickle cell disease (SCD) is a genetic blood disorder characterized by a painful vaso-occlusive crisis due to the sickling of red blood cells in capillaries. Complications often lead to liver and renal dysfunctions, contributing to morbidity and mortality, particularly for children under 5. This systematic review and meta-analysis aimed to evaluate the liver and renal functions of people with SCD (HbSS) compared to those without it (HbAA) in Africa.

methodsThe protocol was registered with PROSPERO (CRD42022346771). We searched PubMed, Embase, Web of Science, and Google Scholar using the keywords "liver function", "renal function", "sickle cell disease", and "Africa" on 6th May 2023 for peer-reviewed articles with abstracts in English. We included case-control studies comparing SCD (HbSS) with controls without hemoglobinopathies (HbAA). We used the random-effect model to calculate the pooled average values for the blood tests of people with SCD in RStudio version 4.2.2.

resultsOverall, 17 articles were analyzed from five African countries involving 1312 people with SCD and 1558 controls. The pooled mean difference of liver enzymes aspartate transaminase (AST) was 8.62 (95% CI - 2.99-20.23, I

conclusionPeople with SCD have slightly elevated liver enzymes and estimated glomerular filtration rates compared to controls in Africa. With all the heterogeneity (I SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022346771.

Indexed as

Anemia, Sickle CellKidneyLiverAfricaAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesCase-Control StudiesHumansAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesAfricaLiver functionRenal functionSickle cellSystematic review

Identifiers

PMID39407336
PMCPMC11479572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.