Evidence map›Paper›PMID 39407274›Full record

ArticleJournal of translational medicine2024

Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma.

Lauren Taylor Rosenblum, ReidAnn E Sever, Ryan Gilbert, David Guerrero, Sarah R Vincze, Dominic M Menendez, Peggy A Birikorang, Mikayla R Rodgers, Ambika Parmar Jaswal, Alexander C Vanover and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lauren Taylor Rosenblum *Department of General Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
ReidAnn E Sever *Department of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA.
Ryan GilbertUniversity of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA, 15213, USA.
David GuerreroUniversity of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA, 15213, USA.
Sarah R VinczeDepartment of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA.
Dominic M MenendezDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Peggy A BirikorangDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Mikayla R RodgersDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Ambika Parmar JaswalDepartment of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA.
Alexander C VanoverDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Joseph D LatocheIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Angel G CortezIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Kathryn E DayIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Lesley M FoleyIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Chaim T SneidermanDepartment of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA.
Itay RaphaelDepartment of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA.
T Kevin HitchensIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Jessie R NedrowIn Vivo Imaging Facility Core, Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Avenue, Pittsburgh, PA, 15232, USA.
Gary Kohanbash *Department of Neurological Surgery, Children's Hospital of Pittsburgh of UPMC, 7131 Rangos Research Building, 530 45th Street, Pittsburgh, PA, 15201, USA. gary.kohanbash2@chp.edu.
W Barry Edwards *Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Marcus M Malek *Department of General Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA. marcus.malek@chp.edu.ORCID 0000-0001-8803-8553

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
Intraoperative dual-labeled molecular tracer to improve surgery on neuroblastomaR01CA277664 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gary Kohanbash, Marcus M. Malek · 2023 to 2026
$2.3M
Intraoperative Molecular Imaging of Metastatic Osteosarcoma with 111In-dinutuximab-IR800F32CA287961 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSENBLUM, LAUREN TAYLOR · 2024 to 2025
$120k
Marjory K. Harmer endowment for Research in Pediatric Pathology Marjory K. Harmer endowment for Research in Pediatric PathologyNCI NIH HHS F32 CA287961NCI NIH HHS P30 CA047904NCI NIH HHS PAR-20-043NCI NIH HHS R01 CA277664NCI NIH HHS T32 CA113263Richard King Mellon Foundation Mellon Scholar AwardUniversity of Pittsburgh Funds University of Pittsburgh Funds
6 · The paper itself

Abstract

backgroundSurgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in children. Safely locating and resecting primary tumor and remote deposits of disease remains a significant challenge, resulting in high rates of complications and incomplete surgery, worsening outcomes. Intraoperative molecular imaging (IMI) uses targeted radioactive or fluorescent tracers to identify and visualize tumors intraoperatively. GD2 was selected as an IMI target, as it is highly overexpressed in neuroblastoma and minimally expressed in normal tissue.

methodsGD2 expression in neuroblastoma cell lines was measured by flow cytometry. DTPA and IRDye

results

conclusionsWe have developed a dual-labeled anti-GD2 antibody-based tracer that incorporates In-111 and IRDye

Indexed as

GangliosidesMolecular ImagingNeuroblastomaAnimalsBenzenesulfonatesCell Line, TumorFemaleHumansIndolesMiceMice, NudeMolecular ProbesTissue DistributionBenzenesulfonatesganglioside, GD2GangliosidesIndolesIRDye 800CWMolecular ProbesFluorescence guided surgeryGD2Intraoperative molecular imagingMonoclonal antibodyNeuroblastomaRadio-guided surgery

Identifiers

PMID39407274
PMCPMC11476241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.