ArticleBMC sports science, medicine & rehabilitation2024
Erythrocyte nicotinamide adenine dinucleotide concentration is enhanced by systematic sports participation.
Article in BMC sports science, medicine & rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05113914 (The Influence of Age and Physical Fitness Level on the Level of Energy Metabolism and Antioxidant Capacity in Adult Males), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Age and Physical Fitness Level on the Level of Energy Metabolism and Antioxidant Capacity in Adult Males
Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundNicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+), and their reduced forms (NADH and NADPH) are the vital cofactors for most cellular oxidation/reduction reactions and therefore influence most critical pathways in cellular metabolism. This study aimed to predict the trends of age-related changes in erythrocyte NAD+ and NADP+ concentrations in elite athletes compared to untrained controls and to assess whether life-long physical training stimulates favorable adaptations in erythrocyte NAD(P)+ concentrations.
methodsErythrocyte concentrations of NAD+ and NADP+ were measured in 68 elite endurance runners (20-81 years), 58 elite sprinters (21-90 years), and 62 untrained individuals (20-68 years). Linear regression analyses were performed to estimate longitudinal relationships and cross-sectional rates of change between age and erythrocyte NAD+ and NADP+ levels. One-way analysis of variance was used to determine differences between the studied groups.
resultsIn all three groups, the erythrocyte NAD+ and NADP+ concentrations significantly decreased with advancing age, suggesting gradual deterioration of NAD-related regulatory functions in older individuals. However, the concentration of erythrocyte NAD(P)+, regardless of age category, was higher in the athletic groups compared to less active controls.
conclusionsOur research shows that systematic sports participation, especially of a sprint-oriented nature, can be treated as a natural and effective strategy promoting cellular NAD(P)+ anabolism and thus cells' energy and redox metabolism.
trial registrationThe study was retrospectively registered in the clinical trials registry on 2021-11-09 (NCT05113914).
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