Evidence map›Paper›PMID 39407192›Full record

ArticleBMC public health2024

Association of fish intake with all-cause mortality according to CRP levels or inflammation in older adults: a prospective cohort study.

Hideaki Kurata, Shu Meguro, Yukiko Abe, Takashi Sasaki, Yasumichi Arai, Kaori Hayashi

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Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hideaki KurataDivision of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160-0016, Japan.
Shu MeguroDivision of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160-0016, Japan. shumeg@keio.jp.
Yukiko AbeCentre for Supercentenarian Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-0016, Japan.
Takashi SasakiCentre for Supercentenarian Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-0016, Japan.
Yasumichi AraiCentre for Supercentenarian Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-0016, Japan.
Kaori HayashiDivision of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, 160-0016, Japan.

Funding

Japan Agency for Medical Research and Development JP20jm0210051h0004Japan Society for the Promotion of Science 18H03055JST Research Complex Program JP15667051
6 · The paper itself

Abstract

backgroundThe relationship between inflammatory response, fish consumption, and mortality risk in older individuals is unclear. We investigated whether C-reactive protein (CRP) levels ≥ 0.1 mg/dL, fish intake, and inflammatory responses are associated with all-cause mortality risk in older adults.

methodsThis prospective cohort study included older adults aged 85-89 years from the Kawasaki Aging and Wellbeing Project, who did not require daily care. Cohort was recruited from March 2017 to December 2018 (follow-up ended on December 31, 2021). Dietary assessment was conducted using the Brief Self-Administered Diet History Questionnaire. Multivariate Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for all-cause mortality in the CRP ≥ 0.1 mg/dL group; the CRP < 0.1 mg/dL group was used for reference. Within CRP ≥ 0.1 and < 0.1 mg/dL groups, participants were categorized into tertiles of fish intake. HRs and 95% CIs for all-cause mortality in the other groups were estimated using the lower tertile group as a reference.

resultsThe study included 996 participants (mean [standard deviation] age, 86.5 [1.37] years; 497 [49.9%] women) with a median CRP level of 0.08 (interquartile range [IQR] = 0.04-0.16). There were 162 deaths during 4,161 person-years of observation; the multivariable-adjusted HR for all-cause mortality in the CRP ≥ 0.1 mg/dL group was 1.86 (95% CI, 1.32-2.62); P < 0.001. In 577 individuals with median (IQR) fish intake of 39.3 g/1000 kcal (23.6-57.6) and CRP level of < 0.1 mg/dL, the multivariable-adjusted HR for all-cause mortality in the higher tertile group of fish intake was 1.15 (0.67-1.97); P = 0.59, non-linear P = 0.84. In 419 individuals with median (IQR) fish intake of 40.7 g/1000 kcal (25.0-60.1) and CRP level of ≥ 0.1 mg/dL, the multivariate-adjusted HR for all-cause mortality in the higher tertile group of fish intake was 0.49 (0.26-0.92); P = 0.026, non-linear P = 0.38, P-value for interaction = 0.040.

conclusionsA negative association between fish intake and all-cause mortality was seen in older adults with elevated CRP levels, which is a mortality risk factor. While the results may be limited owing to stringent methods ensuring impartiality, they offer valuable insights for future research.

trial registrationUMIN000026053. Registered February 24, 2017.

Indexed as

C-Reactive ProteinInflammationMortalityAged, 80 and overAnimalsCause of DeathDietFemaleFishesHumansJapanMaleProspective StudiesSeafoodC-Reactive ProteinAll-cause mortalityC-reactive proteinFish intake

Identifiers

PMID39407192
PMCPMC11481737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.