Evidence map›Paper›PMID 39407083›Full record

ArticleDigestive diseases and sciences2024

EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!

Ryan Alexander, Blake Kassmeyer, Ryan Lennon, Jeffrey Alexander, Diana Snyder, Karthik Ravi

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan AlexanderDepartment of Internal Medicine, Mayo Clinic Rochester, Rochester, USA. alexander.ryan2@mayo.edu.
Blake KassmeyerDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, USA.
Ryan LennonDepartment of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, USA.
Jeffrey AlexanderDepartment of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, USA.
Diana SnyderDepartment of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, USA.
Karthik RaviDepartment of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsData regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.

methodsRetrospective review of 101 patients with histologic PPI-responsive EoE.

results52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.

conclusionsPatients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.

Indexed as

Proton Pump InhibitorsRecurrenceAdultAgedBiopsyEndoscopy, Digestive SystemFemaleGastroesophageal RefluxHumansMaleMiddle AgedRetrospective StudiesProton Pump InhibitorsEosinophilic esophagitisProton pump inhibitorSurveillance

Identifiers

PMID39407083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.