ArticleScientific reports2024
Association between uric acid and the risk of depressive symptoms in US adults: results from NHANES 2005-2018.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Associations of uric acid and lipids with depression, dimensions of depression and anxiety symptoms.Discover mental health · 2025Article
- Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.World journal of psychiatry · 2025Article
- The Influence of Uric Acid Concentration on the Daily Functioning of Patients at an Advanced Age, Based on the Results of Selected Point Scales Routinely Used for the Comprehensive Geriatric Assessment in Poland.Journal of clinical medicine · 2025Article
- Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020.Frontiers in psychiatry · 2025Article
- The uric acid-to-HDL ratio as a predictive biomarker for depression risk in adult women.Frontiers in psychiatry · 2025Article
- Article
- Hyperuricemia in Chinese Patients with Mood Disorders: Prevalence, Related Factors, and Predictive Model.Neuropsychiatric disease and treatment · 2025Article
- Exploring the relationship between the uric acid to high-density lipoprotein cholesterol ratio and depression: a cross-sectional study from NHANES.Scientific reports · 2024Article
- The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study.Frontiers in psychiatry · 2024Article
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Abstract
backgroundThis study explores the relationship between serum uric acid(UA) levels and depression. UA is the final product of purine metabolism in the human body, possessing certain physiological functions such as blood pressure regulation, antioxidation, DNA protection, and anti-aging, thereby drawing attention for its potential role in preventing and treating depression.
methodsThis cross-sectional study includes 32,424 participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018, generating a nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum uric acid concentration was measured using the uricase-peroxidase coupled method, and participants were divided into quartiles of serum uric acid concentration. Weighted data were calculated according to analysis guidelines. The association between serum uric acid and depressive symptoms was analyzed using weighted multivariable logistic regression models and restricted cubic spline regression analyses. Subgroup analyses were also performed.
resultsAmong 32,424 participants, 3,421 were defined as having depressive symptoms. The crude prevalence of depressive symptoms was 10.5% (weighted prevalence: 9.086% [95% confidence interval: 9.032-9.139%]). Compared with the first quartile, individuals with higher UA levels had a decreased risk of depressive symptoms by 9% (OR: 0.910, 95% CI: 0.797-10.40), 14.6% (OR: 0.854, 95% CI: 0.741-0.983), and 20.5% (OR: 7795, 95% CI: 0.680-0.930), respectively. Further restricted cubic spline regression analysis revealed a nonlinear association between UA and depressive symptoms, with an inflection point of 319.72 µmol/L. Subgroup multivariable weighted logistic regression analysis found that the association between UA and the risk of depressive symptoms remained consistent across all subgroups, demonstrating high stability and reliability.
conclusionThis study emphasizes a significant nonlinear negative correlation between serum uric acid and depressive symptoms. This suggests that proper control of serum uric acid levels may play a role in preventing and treating depression.
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