Evidence map›Paper›PMID 39406760›Full record

ArticleScientific reports2024

Cardiovascular risks and endothelial dysfunction in reproductive-age women with endometriosis.

Julia M Smyk, Zuzanna Danielecka, Maja Kotowska, Mateusz Zawadka, Paweł Andruszkiewicz, Michał Grąt, Renata Główczyńska, Marcin Grabowski, Aleksandra Gąsecka, Ewa Romejko-Wolniewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia M Smyk1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland. julia.lekarski@gmail.com.
Zuzanna Danielecka1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland.
Maja Kotowska1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland.
Mateusz ZawadkaDepartment of Anaesthesia and Intensive Care, Medical University of Warsaw, Warsaw, Poland.
Paweł AndruszkiewiczDepartment of Anaesthesia and Intensive Care, Medical University of Warsaw, Warsaw, Poland.
Michał GrątDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Renata Główczyńska1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland.
Marcin Grabowski1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland.
Aleksandra Gąsecka1st Chair, Department of Cardiology, Medical University of Warsaw, Banacha 1a, 09-097, Warsaw, Poland.
Ewa Romejko-Wolniewicz2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Funding

Warszawski Uniwersytet Medyczny 43/M/MG/N/21
6 · The paper itself

Abstract

Endometriosis is a prevalent gynecological condition, affecting around 10% of reproductive-age women. Inflammatory processes associated with endometriosis may contribute to endothelial dysfunction. Increased skin accumulation of advanced glycation end-products (AGEs), reflecting arterial stiffness, potentially links endometriosis with elevated risk of cardiovascular events. We hypothesized that patients with endometriosis have impaired endothelial function as well as increased arterial stiffness and AGE skin accumulation, compared to healthy controls. We compared endothelial function, arterial stiffness, and levels of AGEs in patients suffering from endometriosis and in healthy controls. The study included 45 women aged 20 to 40: 21 patients with endometriosis and 24 healthy controls, matched in terms of age, BMI, and blood pressure values. Endo-PAT 2000 device was used for non-invasive assessment of (i) endothelial function, expressed as Reactive Hyperemia Index (RHI), and (ii) arterial stiffness, expressed as Augmentation Index (AI) and Augmentation Index at 75 heart beats/min (AI@75). Endothelial dysfunction was defined as an RHI value ≤ 1.67. AGE Reader device was used for non-invasive evaluation of skin AGE level accumulation. Patients with endometriosis had lower mean RHI values (1.69 ± 0.54 vs. 2.02 ± 0.48, p = 0.037) and a higher prevalence of endothelial dysfunction, (52.4% vs. 20.8%, p = 0.027) compared to healthy controls. Skin AGE level was higher in patients with endometriosis, compared to controls (2.00 ± 0.57 vs. 1.70 ± 0.24, p = 0.013). There were no significant differences in AI and AI@75 between the two groups. Patients with endometriosis have impaired endothelial function and higher AGE skin accumulation, which are well-established preclinical manifestations of increased cardiovascular risk. There is a great need for comprehensive cardiovascular risk assessments in women with endometriosis to prevent the development of potential atherosclerotic-based complications.

Indexed as

Cardiovascular DiseasesEndometriosisEndothelium, VascularGlycation End Products, AdvancedVascular StiffnessAdultCase-Control StudiesFemaleHeart Disease Risk FactorsHumansRisk FactorsSkinYoung AdultGlycation End Products, AdvancedAGE readerCardiovascular riskEndometriosisEndoPAT 2000Endothelial dysfunction

Identifiers

PMID39406760
PMCPMC11480084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.