Evidence map›Paper›PMID 39406593›Full record

ArticleTrends in pharmacological sciences2024

MICUs protect the heart by regulating mitochondrial calcium.

Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Julia C Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ulas OzkuredeDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Shanmugasundaram PakkiriswamiDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Julia C LiuDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: julialiu@umn.edu.

Funding

Modulating mitochondrial calcium in cardiac homeostasis and diseaseR01HL164491 · NHLBI · UNIVERSITY OF MINNESOTA · PI Julia Chang Liu · 2022 to 2026
$2.2M
NHLBI NIH HHS R01 HL164491
6 · The paper itself

Abstract

Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.

Indexed as

CalciumCalcium ChannelsMitochondria, HeartAnimalsCalcium-Binding ProteinsCation Transport ProteinsHeart DiseasesHumansMitochondrial Membrane Transport ProteinsCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsMICU1 protein, humanMICU2 protein, humanmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinscalciumEMREheartMCUMICU1MICU2mitochondria

Identifiers

PMID39406593
PMCPMC11637328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.