Evidence map›Paper›PMID 39406513›Full record

ArticleAJNR. American journal of neuroradiology2025

Additional Diagnostic Value of Conebeam CT Myelography Performed after Digital Subtraction Myelography for Detecting CSF-Venous Fistulas.

Ajay A Madhavan, Niklas Lutzen, Jeremy K Cutsforth-Gregory, Wouter I Schievink, Michelle L Kodet, Ian T Mark, Pearse P Morris, Steven A Messina, John T Wald, Waleed Brinjikji

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Conebeam CT Myelography for the Detection of Spinal CSF Leaks.AJNR. American journal of neuroradiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ajay A MadhavanFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota madhavan.ajay@mayo.edu.ORCID 0000-0003-1794-4502
Niklas LutzenDepartment of Neurology (N.L.), Mayo Clinic, Rochester, Minnesota.
Jeremy K Cutsforth-GregoryDepartment of Neuroradiology (J.K.C.-G.), University Medical Center Freiburg, Freiburg, Delaware.ORCID 0000-0002-5689-4424
Wouter I SchievinkCedars-Sinai Medical Center (W.I.S.), Neurosurgery, Los Angeles, California.ORCID 0000-0001-5494-0688
Michelle L KodetFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4317-1697
Ian T MarkFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-4036-2992
Pearse P MorrisFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9013-5624
Steven A MessinaFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-0861-8628
John T WaldFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5187-2333
Waleed BrinjikjiFrom the Division of Neuroradiology, Department of Radiology (A.A.M., M.L.K., I.T.M., P.P.M., S.A.M., J.T.W., W.B.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5271-5524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCSF-venous fistulas (CVFs) are a common cause of spontaneous intracranial hypotension. The diagnosis and precise localization of these fistulas hinges on specialized myelographic techniques, which mainly include decubitus digital subtraction myelography and decubitus CT myelography (by using either energy-integrating or photon-counting detector CT). A previous case series showed that conebeam CT myelography (CB-CTM), performed as an adjunctive tool with digital subtraction myelography, increased the detection of CVFs. Here, we sought to determine the additive yield of CB-CTM for CVF detection in a consecutive series of patients with spontaneous intracranial hypotension who underwent concurrent decubitus digital subtraction myelography and CB-CTM. MATERIALS AND

methodsWe retrospectively searched our institutional database for all consecutive patients who underwent decubitus digital subtraction myelography with adjunctive CB-CTM between August 5, 2021 and August 5, 2024. We excluded any patients harboring extradural CSF on spine imaging, not meeting International Classification of Headache Disorders, 3rd edition criteria for spontaneous intracranial hypotension, or not having undergone technically successful CB-CTM in combination with digital subtraction myelography. All myelographic images were independently reviewed by 2 neuroradiologists. We calculated the diagnostic yield of both myelographic tests for localizing a CVF.

resultsWe identified 100 patients who underwent decubitus digital subtraction myelography with adjunctive conebeam CT. We excluded 15 patients based on above criteria. Fifty-nine of 85 patients had a single definitive CVF. Among positive cases, the fistula was visible on digital subtraction myelography in 38 of 59 patients and visible on CB-CTM in 59 of 59 patients. In 26 of 85 patients, no definitive fistula was identified by either technique.

conclusionsCB-CTM increased the diagnostic yield for CVF detection and may be a useful addition to digital subtraction myelography.

Indexed as

Angiography, Digital SubtractionCone-Beam Computed TomographyIntracranial HypotensionMyelographyAdultAgedFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID39406513
PMCPMC12091977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.