Evidence map›Paper›PMID 39406384›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Tumor suppressors RBL1 and PTEN are epigenetically silenced in IPF mesenchymal progenitor cells by a CD44/Brg1/PRMT5 regulatory complex.

Libang Yang, Hong Xia, Karen Smith, Adam J Gilbertsen, Aiham H Jbeli, Juan E Abrahante, Peter B Bitterman, Craig A Henke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Libang YangDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.
Hong XiaDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.
Karen SmithDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.
Adam J GilbertsenDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0001-7998-912X
Aiham H JbeliDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0001-6804-4737
Juan E AbrahanteMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States.
Peter B BittermanDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-7995-7117
Craig A HenkeDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-7484-1131

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Integrin-Matrix Regulation of IPF Fibroblast PhenotypeR01HL125227 · NHLBI · UNIVERSITY OF MINNESOTA · PI HENKE, CRAIG A · 2015 to 2018
$1.8M
NCI NIH HHS P30 CA077598NHLBI NIH HHS R01 HL125227
6 · The paper itself

Abstract

The idiopathic pulmonary fibrosis (IPF) lung contains mesenchymal progenitor cells (MPCs) that display durable activation of oncogenic signaling and cell-autonomous fibrogenicity in vivo. Prior work identified a CD44/Brg1/PRMT5 nuclear regulatory module in IPF MPCs that increased the expression of genes positively regulating pluripotency and self-renewal. Left unanswered is how IPF MPCs evade negative regulation of self-renewal. Here we sought to identify mechanisms disabling negative regulation of self-renewal in IPF MPCs. We demonstrate that expression of the tumor suppressor genes

Indexed as

DNA HelicasesHyaluronan ReceptorsIdiopathic Pulmonary FibrosisMesenchymal Stem CellsNuclear ProteinsProtein-Arginine N-MethyltransferasesPTEN PhosphohydrolaseTranscription FactorsAnimalsEpigenesis, GeneticHumansMiceRetinoblastoma-Binding Protein 2CD44 protein, humanDNA HelicasesHyaluronan ReceptorsNuclear ProteinsPRMT5 protein, humanPrmt5 protein, mouseProtein-Arginine N-MethyltransferasesPTEN PhosphohydrolasePTEN protein, humanRetinoblastoma-Binding Protein 2SMARCA4 protein, humanTranscription Factorsepigenesisfibrogenic mesenchymal progenitor cellsidiopathic pulmonary fibrosis

Identifiers

PMID39406384
PMCPMC11684952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.