ArticleImmunity2024
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- Mrpl50 integrates glucolipotoxicity with hypoxia-inducible factor 1 alpha signaling to drive diabetic kidney disease.The Journal of biological chemistry · 2026Article
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes.Inflammation and regeneration · 2026Review
- ACSL5 programs fatty acid metabolism and mitochondrial fitness to sustain pathogenic T cells and exacerbate Sjögren's syndrome.International journal of biological sciences · 2026Article
- Intestinal tissue-resident memory T cells: Characteristics, spatial heterogeneity, age-related dynamics, and roles in disease regulation.Journal of advanced research · 2026Review
- The Janus face of tissue-resident memory T cells: dual programming in tumor immune surveillance and autoimmune pathology.Frontiers in immunology · 2026Review
- Bioinspired catalytic nanogel as an inflammatory cascade-targeted therapeutic for rheumatoid arthritis.Journal of nanobiotechnology · 2025Article
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Perturbomics: CRISPR-Cas screening-based functional genomics approach for drug target discovery.Experimental & molecular medicine · 2025Review
- MultiplexedbioRxiv : the preprint server for biology · 2025Article
- Identification of Senescence-Related Genes for the Prediction of Ulcerative Colitis Based on Interpretable Machine Learning Models.Journal of inflammation research · 2025Article
- Angel and devil: the protective immunity and pathogenic inflammation of tissue resident memory T cells in ulcerative colitis.Frontiers in immunology · 2025Review
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Authors and funding
22 authors.
Jana L RaynorDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Nicholas CollinsMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cliff GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jordy SaraviaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Seon Ah LimDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peipei ZhouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yan WangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yu SunDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Isabel RischDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Haoran HuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Renqiang SunDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sharad ShresthaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hongling HuangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jon P ConnellyCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shondra M Pruett-MillerCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Miguel Reina-CamposSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA; La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ananda W GoldrathSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, San Diego, CA, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: hongbo.chi@stjude.org.
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MIntegrating systems immunology with immunometabolism and cancer immunityR35CA253188 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2021 to 2026
$6.0MRegulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MTranscriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MBidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3MT cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0MNutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2MNCI NIH HHS P30 CA021765NCI NIH HHS R35 CA253188NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI067545NIAID NIH HHS R37 AI105887
Abstract
Nutrient availability and organelle biology direct tissue homeostasis and cell fate, but how these processes orchestrate tissue immunity remains poorly defined. Here, using in vivo CRISPR-Cas9 screens, we uncovered organelle signaling and metabolic processes shaping CD8
Indexed as
CD8-Positive T-LymphocytesCRISPR-Cas SystemsImmunologic MemoryLysosomesMemory T CellsMitochondriaNutrientsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell DifferentiationIntestinesMiceMice, Inbred C57BLMice, KnockoutMitochondrial ProteinsSignal TransductionBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMitochondrial ProteinsNutrientsTcfeb protein, mouseadaptive immunityCD8 T celldietary interventionimmunometabolismlysosomemitochondriatissue-resident memory
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