Evidence map›Paper›PMID 39405632›Full record

Trial reportParkinsonism & related disorders2024

Supplemental ambient lighting intervention to improve sleep in Parkinson's disease: A pilot trial.

Andrea S Yoo, Adina Wise, Roberto A Ortega, Deborah Raymond, Barbara Plitnick, Jennifer Brons, Judy Liang, Susan B Bressman, Mengxi Yang, David Pedler and 2 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A double-blind, controlled trial of circadian effective light therapy in patients with Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Trial
  3. Home-Based Tailored Light Therapy for Sleep, Mood, and Cognitive Outcomes in Mild Cognitive Impairment: A Randomized Trial.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea S YooDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: suy9023@med.cornell.edu.
Adina WiseDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: adina.wise@mountsinai.org.
Roberto A OrtegaDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA; Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: roberto.ortega@einsteinmed.edu.
Deborah RaymondDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: deborah.raymond@mountsinai.org.
Barbara PlitnickLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, USA. Electronic address: barbara.plitnick@mountsinai.org.
Jennifer BronsLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, USA. Electronic address: jennifer.brons@mountsinai.org.
Judy LiangDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: jliang@nyee.edu.
Susan B BressmanDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: susan.bressman@mountsinai.org.
Mengxi YangDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: mengxi.yang@mountsinai.org.
David PedlerLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, USA. Electronic address: david.pedler@mountsinai.org.
Mariana G FigueiroLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, USA. Electronic address: mariana.figueiro@mountsinai.org.
Rachel Saunders-PullmanDepartment of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA. Electronic address: rachel.saunders-pullman@mountsinai.org.

Funding

Methodology Issues in a Tailored Light Treatment for Persons with DementiaR01AG034157 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI FIGUEIRO, MARIANA GROSS · 2010 to 2024
$7.9M
Dissecting Oligogenic Biomarkers in Ashkenazi Jews with Parkinson DiseaseU01NS107016 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OZELIUS, LAURIE J., SAUNDERS-PULLMAN, RACHEL · 2019 to 2023
$6.6M
The long-term impact of light intervention on sleep physiology and cognition in mild cognitive impairmentR01AG062288 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI FIGUEIRO, MARIANA GROSS, MEDNICK, SARA CAROLE · 2019 to 2023
$3.9M
NIA NIH HHS R01 AG034157NIA NIH HHS R01 AG062288NINDS NIH HHS U01 NS107016
6 · The paper itself

Abstract

importanceSleep disturbances in Parkinson's disease (PD) are common and often adversely affect quality of life. Light therapy has benefited sleep quality and mood outcomes in various populations but results to date with conventional light therapy boxes in PD patients have been mixed. We hypothesized that a passive lighting intervention, applied in the morning and designed to maximally affect the circadian system, would improve measures of sleep and mood in PD patients.

methodsIn this single-arm, within-subjects intervention study, baseline objective sleep (actigraphy), subjective sleep quality (questionnaires), and subjective mood (questionnaires) data were collected for 1 week. Lighting was then administered to participants via table/floor lamps installed in the home or via personal light therapy glasses for 2 h in the morning, 7 days per week, over the following 4-week period. Post-intervention data for the same outcomes were collected during the final week of the intervention period.

resultsAmong 20 participants (12 women, 8 men; mean [SD] age 72.1 [9.5] years, disease duration 9.0 [5.2] years), objective sleep duration increased significantly by 28.5 min (p = 0.029) and objective sleep time increased significantly by 19.9 min (p = 0.026).

conclusionPassive and easily administered lighting interventions for improving sleep in PD patients hold promise as a treatment for mitigating symptoms and improving quality of life in PD.

Indexed as

Parkinson DiseasePhototherapySleep Wake DisordersActigraphyAgedAged, 80 and overFemaleHumansLightingMaleMiddle AgedPilot ProjectsQuality of LifeSleep QualityActigraphyCircadian-effective light exposuresCircadian systemLight therapyMoodParkinson's diseaseSleep quality

Identifiers

PMID39405632
PMCPMC12281491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.