Evidence map›Paper›PMID 39405353›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

UBR-5 and UBE2D mediate timely exit from stem fate via destabilization of poly(A)-binding protein PABP-2 in cell state transition.

Jose Francisco Calva Moreno, George Jose, Yi M Weaver, Benjamin P Weaver

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. AScience signaling · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jose Francisco Calva MorenoDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4440-4475
George JoseDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0009-0008-2163-3591
Yi M WeaverDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-8993-2001
Benjamin P WeaverDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-0830-213X

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Proteolytic Mechanisms Mediating Diverse Non-Apoptotic Caspase FunctionsR35GM133755 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin P. Weaver · 2019 to 2026
$3.7M
Unmasking p38 MAPK Functions in Lysosome Homeostasis during Development and AgingR21AG086710 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WEAVER, BENJAMIN P. · 2024 to 2024
$451k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM133755HHS | NIH | National Institute on Aging (NIA) R21AG086710NIA NIH HHS R21 AG086710NIGMS NIH HHS R35 GM133755NIH HHS P40 OD010440Welch Foundation (The Welch Foundation) I-2022-20190330
6 · The paper itself

Abstract

UBR5 E3 ligase has been associated with cancer susceptibility and neuronal integrity, with functions in chromatin regulation and proteostasis. However, the functions of

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesAnimalsCell DifferentiationPoly(A)-Binding ProteinsStem CellsCaenorhabditis elegans Proteinslet-70 protein, C eleganspabp-2 protein, C elegansPoly(A)-Binding ProteinsUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesUBR-5 protein, C elegansagingHECT E3 ligasepoly(A)-binding proteinproteostasisstem fate

Identifiers

PMID39405353
PMCPMC11513905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.