Evidence map›Paper›PMID 39405096›Full record

ArticleeLife2024

Light-driven synchronization of optogenetic clocks.

Maria Cristina Cannarsa, Filippo Liguori, Nicola Pellicciotta, Giacomo Frangipane, Roberto Di Leonardo

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Cristina CannarsaDepartment of Physics, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0009-0009-4126-4022
Filippo LiguoriDepartment of Physics, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0000-0003-2859-6953
Nicola PellicciottaDepartment of Physics, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0000-0002-7105-9566
Giacomo FrangipaneDepartment of Physics, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0000-0002-1533-4754
Roberto Di LeonardoDepartment of Physics, Sapienza University of Rome, Roma, Italy.ORCID https://orcid.org/0000-0002-5020-0663

Funding

European Research Council 834615Ministero dell'Università e della Ricerca R20R4X8ZEL
6 · The paper itself

Abstract

Synthetic genetic oscillators can serve as internal clocks within engineered cells to program periodic expression. However, cell-to-cell variability introduces a dispersion in the characteristics of these clocks that drives the population to complete desynchronization. Here, we introduce the optorepressilator, an optically controllable genetic clock that combines the repressilator, a three-node synthetic network in

Indexed as

Escherichia coliLightOptogeneticsBiological ClocksCircadian ClocksModels, Theoreticalcomputational biologyE. colinonlinear dynamicsoptogeneticsphysics of living systemssynthetic biologysystems biology

Identifiers

PMID39405096
PMCPMC11479589

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.