Evidence map›Paper›PMID 39405027›Full record

ArticleEuropean geriatric medicine2024

The association between oral frailty and HbA1c among older adults with T2DM: the chain mediating effect of nutritional status and physical frailty.

Jian Yu, Anna Ye, Yang Fei, Dandan Wang, Yu Zhang, Xianwen Li

Abstract read
PubMed Publisher
In one paragraph

Article in European geriatric medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian Yu *Department of Endocrinology, The First Affiliated Hospital With Nanjing Medical University (Jiangsu Province Hospital), Nanjing, 210029, LA, China.
Anna Ye *Department of Endocrinology, The First Affiliated Hospital With Nanjing Medical University (Jiangsu Province Hospital), Nanjing, 210029, LA, China.
Yang FeiSchool of Nursing, Nanjing Medical University, Nanjing, 211166, LA, China.
Dandan WangKangda College of Nanjing Medical University, Lianyungang, 222000, LA, China.
Yu ZhangChangZhou Vocational Institute of Textile and Garment, ChangZhou, 213164, LA, China.
Xianwen LiSchool of Nursing, Nanjing Medical University, Nanjing, 211166, LA, China. xwli0201@njmu.edu.cn.ORCID 0000-0003-1935-2391

Funding

Connotation Construction Project of Nanjing Medical University for Priority Academic of Nursing Science 2022-12Graduate Research and Innovation Projects of Jiangsu Province Z2020028Ministry of Education of Humanities and Social Science Project 22YJCZH08Philosophy and Social Science Research Projects of Jiangsu Universities 2022SJYB0298
6 · The paper itself

Abstract

objectivesThe present study aimed to explore the association between oral frailty and glycated hemoglobin (HbA1c), and the chain mediating role of nutritional status and physical frailty among older adults with type 2 diabetes mellitus (T2DM).

methodsPatients with T2DM aged > 60 years were recruited from the endocrinology department of a national metabolic center from October 2023 to March 2024. Oral frailty, nutritional status, and physical frailty were assessed with Oral Frailty Index-8 (OFI-8), the Nutrition Risk Screening 2002 (NRS2002), Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index (FRAIL), respectively. Their HbA1c were collected at the same time. In order to reveal the interaction and influence between multiple variables, chain mediation analyses were conducted using the "Process" macro in SPSS 26.0 to estimate the direct and indirect effects of oral frailty on nutritional status, physical frailty and HbA1c.

resultsA total of 292 participants (50.7% male) were enrolled in this study at a median age of 70.0 (65.2, 76.0) years and a T2DM disease duration of (16.5 ± 9.4) years. After adjustment for age, oral frailty of older people with T2DM significantly positively predicted their HbA1c (β = 0.198, P < 0.001). In addition, oral frailty affect HbA1c through two indirect pathways, including an independent mediating effect of physical frailty (effect = 0.046) and a chain-mediating effect of nutritional status and physical frailty (effect = 0.004).

conclusionsOur findings suggest that less oral frailty of older adults with T2DM could optimize their nutritional status and physical frailty and, thus, their HbA1c. Consequently, improving oral health is expected to be a promising intervention target for reaching optimal glycaemic control in older adults with T2DM.

Indexed as

Diabetes Mellitus, Type 2Frail ElderlyFrailtyGlycated HemoglobinNutritional StatusAgedAged, 80 and overCross-Sectional StudiesFemaleGeriatric AssessmentHumansMaleMiddle AgedGlycated HemoglobinGlycated hemoglobin (HbA1c)Older adultsOral frailtyPhysical frailtyType 2 diabetes mellitus (T2DM)

Identifiers

PMID39405027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.