Evidence map›Paper›PMID 39405026›Full record

ArticleEJNMMI research2024

Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas.

Theodorus J P Jansen, Sevilay Tokgöz, Mijke Buitinga, Sanne A M van Lith, Lieke Joosten, Cathelijne Frielink, Esther M M Smeets, Martijn W J Stommel, Marion B van der Kolk, Bastiaan E de Galan and 3 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03889496 naterminatednot on this map

Quantitative GLP-1 Receptor Imaging Correlated to ex Vivo Distribution of In-111-exendin

TypeinterventionalSponsorRadboud University Medical CenterRan2015 to 2021Enrolled12ConditionsDiabetes MellitusArmsindium-111-exendin SPECT/CT
NCT04733508 naunknown statusnot on this map

Glucagon Like Peptide 1 Receptor (GLP1R) Expression and Beta-cell Mass in Patients With Type 2 Diabetes - the Role of Glucose Homeostasis on Uptake of Beta-cell Tracer Exendin-4

TypeinterventionalSponsorRadboud University Medical CenterRan2019 to 2022Enrolled28ConditionsDiabetes Mellitus, Diabetes Mellitus, Type 2Arms111In-DTPA-exendin-4, IRDye800CW-exendin-4
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Theodorus J P JansenDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-6466-7838
Sevilay TokgözDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0009-0009-7597-8170
Mijke BuitingaNutrition and Movement Sciences, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-4202-2473
Sanne A M van LithDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8584-2546
Lieke JoostenDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4427-8664
Cathelijne FrielinkDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Esther M M SmeetsDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-8350-2131
Martijn W J StommelDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4257-5254
Marion B van der KolkDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-0294-0496
Bastiaan E de GalanInternal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-1255-7741
Maarten BromDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-5755-1477
Marti BossDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-5837-1803
Martin GotthardtDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. Martin.Gotthardt@radboudumc.nl.ORCID http://orcid.org/0000-0002-6537-7744

Funding

Diabetes Fonds 2015-81-1845FP7 Ideas: European Research Council 602812Innovative Medicines Initiative 115797Innovative Medicines Initiative 948268JDRF 2-SRA-2014-266-M-BZonMw 95105008
6 · The paper itself

Abstract

backgroundEstimation of beta cell mass is currently restricted to evaluating pancreatic tissue samples, which provides limited information. A non-invasive imaging technique that reliably quantifies beta cell mass enables monitoring of changes of beta cell mass during the progression of diabetes mellitus and may contribute to monitoring of therapy effectiveness. We assessed the specificity of radiolabelled exendin for beta cell mass quantification in humans. Fourteen adults with pancreas tumours were injected with

conclusionRadiolabelled exendin specifically accumulates in the islets of Langerhans in human pancreas tissue. The clear overlap between regions positive for insulin and the GLP-1 receptor substantiate the beta cell specificity of the tracer. Radiolabelled exendin is therefore a valuable imaging agent for human beta cell mass quantification and has the potential to be used for a range of applications, including improvement of diabetes treatment by assessment of the effects of current and novel diabetes therapies on the beta cell mass.

trial registrationClinicalTrials.gov NCT03889496, registered 26,032,019, URL https://clinicaltrials.gov/study/NCT03889496?term=NCT03889496 . CLINICALTRIALS: gov NCT04733508, registered 02022021, URL https://clinicaltrials.gov/study/NCT04733508 .

Indexed as

Beta cell massEndocrine-to-exocrine ratioHuman pancreasRadiolabelled exendinSPECT/CT imaging

Identifiers

PMID39405026
PMCPMC11480297

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.