Evidence map›Paper›PMID 39405018›Full record

ArticleLa Radiologia medica2024

Dual-energy CT late arterial phase iodine maps for the diagnosis of acute non-occlusive mesenteric ischemia.

Tommaso D'Angelo, Giuseppe M Bucolo, Ibrahim Yel, Vitali Koch, Leon D Gruenewald, Simon S Martin, Leona S Alizadeh, Thomas J Vogl, Giorgio Ascenti, Ludovica R M Lanzafame and 3 more

Abstract read
In one paragraph

Article in La Radiologia medica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tommaso D'AngeloDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy. tommasodang@gmail.com.ORCID http://orcid.org/0000-0003-0004-6378
Giuseppe M BucoloDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy.
Ibrahim YelDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Vitali KochDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Leon D GruenewaldDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Simon S MartinDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Leona S AlizadehDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Thomas J VoglDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Giorgio AscentiDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy.
Ludovica R M LanzafameDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy.
Silvio MazziottiDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy.
Alfredo BlandinoDiagnostic and Interventional Radiology Unit, BIOMORF Department, University Hospital, Policlinico G. MartinoMessina, Via Consolare Valeria 1, 98100, Messina, Italy.
Christian BoozDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the diagnostic accuracy of dual-energy CT (DECT) iodine maps in comparison to conventional CT series for the assessment of non-occlusive mesenteric ischemia (NOMI). MATERIAL AND

methodsWe evaluated data from 142 patients (72 men; 50.7%) who underwent DECT between 2018 and 2022, with surgically confirmed diagnosis of NOMI. One board-certified radiologist performed region of interest (ROI) measurements in bowel segments on late arterial (LA) and portal venous (PV) phase DECT iodine maps as well as LA conventional series, in both ischemic and non-ischemic bowel loops, using surgical reports as reference standard, and in a control group of 97 patients. Intra- and inter-reader agreement with a second board-certified radiologist was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to calculate the optimal threshold for discriminating ischemic from non-ischemic bowel segments. Subjective image rating of LA and PV iodine maps was performed.

resultsDECT-based iodine concentration (IC) measurements showed significant differences in LA phase iodine maps between ischemic (median:0.72; IQR 0.52-0.91 mg/mL) and non-ischemic bowel loops (5.16; IQR 3.45-6.31 mg/ml) (P <.0001). IC quantification on LA phase revealed an AUC of 0.966 for the assessment of acute bowel ischemia, significantly higher compared to both IC quantification based on PV phase (0.951) and attenuation values evaluated on LA conventional CT series (0.828). Excellent intra-observer and strong inter-observer agreements were observed for the quantification of iodine concentration. Conversely, weak inter-observer agreement was noted for conventional HU assessments. The optimal LA phase-based IC threshold for assessing bowel ischemia was 1.34 mg/mL, yielding a sensitivity of 100% and specificity of 96.48%.

conclusionIodine maps based on LA phase significantly improve the diagnostic accuracy for the assessment of NOMI compared to conventional CT series and PV phase iodine maps.

Indexed as

Contrast MediaMesenteric IschemiaTomography, X-Ray ComputedAcute DiseaseAgedAged, 80 and overFemaleHumansIodineMaleMiddle AgedRadiography, Dual-Energy Scanned ProjectionRetrospective StudiesROC CurveSensitivity and SpecificityContrast MediaIodineAcute mesenteric ischemia; Dual energy; Computed tomography; Bowel diseases; Mesenteric vascular insufficiency

Identifiers

PMID39405018
PMCPMC11554692

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.