Evidence map›Paper›PMID 39404976›Full record

ArticleHead and neck pathology2024

Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study.

Paolo Boscolo-Rizzo, Jerry Polesel, Anna Menegaldo, Egidio Sia, Marco Stellin, Giancarlo Tirelli

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Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paolo Boscolo-RizzoDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0002-4635-7959
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. polesel@cro.it.ORCID http://orcid.org/0000-0001-9381-1520
Anna MenegaldoUnit of Otolaryngology, AULSS 2-Marca Trevigiana, Treviso, Italy.ORCID http://orcid.org/0000-0002-2253-8149
Egidio SiaDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0003-0343-9070
Marco StellinUnit of Otolaryngology, AULSS 2-Marca Trevigiana, Treviso, Italy.ORCID http://orcid.org/0000-0002-8947-9104
Giancarlo TirelliDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0002-7871-2011

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccuracy in the diagnosis of HPV-associated oropharyngeal carcinoma (OPSCC) of a rapid, low-cost lateral flow immunochromatographic assay for detecting E6 oncoprotein of HPV-16 and HPV-18 was previously evaluated in a small pilot study. This cross-sectional study aimed to assess on a large case series the sensitivity and specificity of E6 oncoprotein as a diagnostic marker for HPV-associated carcinogenesis in OPSCC.

methods137 consecutive patients with histologically confirmed OPSCC were enrolled in two hospitals in Northeast Italy. HPV status was determined by PCR for HPV DNA and p16

resultsOf the 137 OPSCC cases, 68 (49.6%) were HPV-associated, testing positive for both high-risk HPV-DNA and p16

conclusionThe low-cost lateral flow immunochromatographic assay for detecting HPV16/18 E6 oncoproteins confirmed high accuracy for identifying HPV-associated OPSCC, particularly in primary tumors, suggesting its potential as a valuable diagnostic tool in clinical practice. Its rapid diagnostic capability could significantly accelerate the process of treatment decision-making, enhancing the timely management of patients.

Indexed as

Human papillomavirus 18Lymphatic MetastasisOncogene Proteins, ViralOropharyngeal NeoplasmsPapillomavirus InfectionsRepressor ProteinsSensitivity and SpecificityAdultAgedAged, 80 and overBiomarkers, TumorCross-Sectional StudiesDNA-Binding ProteinsFemaleHuman papillomavirus 16Human Papillomavirus VirusesBiomarkers, TumorDNA-Binding ProteinsE6 protein, Human papillomavirus type 16E6 protein, Human papillomavirus type 18Oncogene Proteins, ViralRepressor ProteinsE6 oncoproteinHPVHPV-DNALateral flow immunochromatographic assayOropharyngeal cancerP16Squamous cell carcinoma

Identifiers

PMID39404976
PMCPMC11480278

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.