Evidence map›Paper›PMID 39404972›Full record

ArticleEuropean journal of epidemiology2024

Body fatness across the adult life course and ovarian cancer risk.

Jennifer A Ritonja, Sreenath Madathil, Belinda Nicolau, Kevin L'Espérance, Vikki Ho, Michal Abrahamowicz, Anita Koushik

Abstract read
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Article in European journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer A RitonjaDepartment of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-2813-867X
Sreenath MadathilFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9406-6518
Belinda NicolauDepartment of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-2833-2317
Kevin L'EspéranceUniversité de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-1429-0988
Vikki HoUniversité de Montréal Hospital Research Centre (CRCHUM), Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-0724-7917
Michal AbrahamowiczDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3172-3952
Anita KoushikDepartment of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. anita.koushik@mcgill.ca.ORCID http://orcid.org/0000-0001-5304-7660

Funding

CIHR 491740CIHR PJT-175307Fonds de Recherche du Québec - Santé Fonds de Recherche du Québec - Santé
6 · The paper itself

Abstract

Excess body fatness in late adulthood has been observed to increase ovarian cancer risk, but the association is relatively weak. Body fatness can change over time, and timing may differently influence risk. We used a life course epidemiology approach to identify whether the relation between body fatness and ovarian cancer risk is best described by a critical period, accumulation or sensitive period hypothesis. In a population-based case-control study of ovarian cancer in Montreal, Canada (2011-16), data on body mass index (BMI) at each decade starting at age 20 was available. Among 363 cases and 707 controls aged ≥ 50 years, we used a Bayesian relevant life course exposure model to estimate the relative importance of BMI for three pre-specified periods across the adult life course, i.e., early childbearing years, late childbearing years, and peri/postmenopause, on ovarian cancer risk. The accumulation hypothesis best described BMI in relation to ovarian cancer overall, with an odds ratio (OR) for the lifetime effect of BMI (per 5 kg/m

Indexed as

Body Mass IndexOvarian NeoplasmsAdipose TissueAdultAgedBayes TheoremCanadaCase-Control StudiesFemaleHumansMiddle AgedObesityRisk FactorsBody fatnessCase-control studyLife course epidemiologyOvarian cancer

Identifiers

PMID39404972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.