Observational studyJournal of neuro-oncology2025
DTI fiber-tracking parameters adjacent to gliomas: the role of tract irregularity value in operative planning, resection, and outcome.
Observational study in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mapping and anatomo-surgical techniques for language preservation in brain tumours (Review).Experimental and therapeutic medicine · 2026Review
- Article
- Review
- A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.Human brain mapping · 2025Article
- Long-term clinical prognosis of patients with gliomas infiltrating corticospinal tract on DTI tractography.Chinese neurosurgical journal · 2025Article
- Advanced MRI, Radiomics and Radiogenomics in Unravelling Incidental Glioma Grading and Genetic Status: Where Are We?Medicina (Kaunas, Lithuania) · 2025Review
- Review
- Spatial Mapping of Glioblastoma Infiltration: Diffusion Tensor Imaging-Based Radiomics and Connectomics in Recurrence Prediction.Brain sciences · 2025Review
- Innovation and technology in neurosurgery oncology.Journal of neuro-oncology · 2025Article
- Confocal Laser Endomicroscopy: Enhancing Intraoperative Decision Making in Neurosurgery.Diagnostics (Basel, Switzerland) · 2025Review
- Preliminary investigation on predicting postoperative glioma recurrences based on a multiparametric radiomics model.Frontiers in oncology · 2025Article
- Fusion of 3D photorealistic lateral-to-medial brain white matter dissection and diffusion tensor imaging for dynamic visualization of key fiber tracts.Brain & spine · 2025Article
- Role of the frontal aslant tract in language preservation and recovery after surgery: a multicenter analysis of patients with left frontal glioma.Frontiers in neurologyArticle
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Authors and funding
11 authors.
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Abstract
purposeThe goal of glioma surgery is maximal tumor resection associated with minimal post-operative morbidity. Diffusion tensor imaging-tractography/fiber tracking (DTI-FT) is a valuable white-matter (WM) visualization tool for diagnosis and surgical planning. Still, it assumes a descriptive role since the main DTI metrics and parameters showed several limitations in clinical use. New applications and quantitative measurements were recently applied to describe WM architecture that surround the tumor area. The brain adjacent tumor area (BAT) is defined as the region adjacent to the gross tumor volume, which contains signal abnormalities on T2-weighted or FLAIR sequences. The DTI-FT analysis of the BAT can be adopted as predictive values and a guide for safe tumor resection.
methodsThis is an observational prospective study on an extensive series of glioma patients who performed magnetic resonance imaging (MRI) with pre-operative DTI-FT analyzed on the BAT by two different software. We examined DTI parameters of Fractional anisotropy (FA mean, min-max), Mean diffusivity (MD), and the shape-metric "tract irregularity" (TI) grade, comparing it with the surgical series' clinical, radiological, and outcome data.
resultsThe population consisted of 118 patients, with a mean age of 60.6 years. 82 patients suffering from high-grade gliomas (69.5%), and 36 from low-grade gliomas (30.5%). A significant inverse relationship exists between the FA mean value and grading (p = 0.001). The relationship appears directly proportional regarding MD values (p = 0.003) and TI values (p = 0.005). FA mean and MD values are susceptible to significant variations with tumor and edema volume (p = 0.05). TI showed an independent relationship with grading regardless of tumor radiological features and dimensions, with a direct relationship with grading, ki67% (p = 0,05), PFS (p < 0.001), and EOR (p < 0.01).
conclusionFA, MD, and TI are useful predictive measures of the clinical behavior of glioma, and TI could be helpful for tumor grading identification and surgical planning.
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