Evidence map›Paper›PMID 39404936›Full record

ReviewMolecular and cellular biochemistry2025

Causes and consequences of DNA double-stranded breaks in cardiovascular disease.

A J Marian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Cardiac phenotypes in LMNA mutations.Current opinion in cardiology · 2025
    Review
  6. Phenotypic diversity of the LMNA mutations.Current opinion in cardiology · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

A J MarianCenter for Cardiovascular Genetic Studies, Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, USA. Ali.J.Marian@uth.tmc.edu.

Funding

Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular AgingR01AG082751 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Ali J Marian · 2023 to 2026
$2.4M
Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic CardiomyopathyR01HL151737 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARIAN, ALI J · 2020 to 2023
$2.0M
National Institute of Aging R01AG082751NHLBI NIH HHS R01 HL151737
6 · The paper itself

Abstract

The genome, whose stability is essential for survival, is incessantly exposed to internal and external stressors, which introduce an estimated 10

Indexed as

Cardiovascular DiseasesDNA Breaks, Double-StrandedDNA RepairAnimalsHumansTranscription, GeneticAgingDNA damageDNA damage response pathwaysDouble-stranded breaksTranscription stress

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.