Evidence map›Paper›PMID 39404933›Full record

ArticleApoptosis : an international journal on programmed cell death2024

Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8

Ke Jin, Dan Zhao, Jun Zhou, Xun Zhang, Yujue Wang, Zhao Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. In vivo study on IL-37 inhibition of malignant melanoma metastasis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  7. [Effects of Electromagnetic Pulses on Exosomes Secretion by A549 Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ke Jin *Department of Oncology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Dan Zhao *Department of Oncology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Jun ZhouSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Xun ZhangDepartment of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 West 2nd Section, First Ring Road, Qingyang District, Chengdu, 610072, Sichuan Province, China.
Yujue WangDepartment of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 West 2nd Section, First Ring Road, Qingyang District, Chengdu, 610072, Sichuan Province, China. wangyujue@med.uestc.edu.cn.
Zhao WuDepartment of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 West 2nd Section, First Ring Road, Qingyang District, Chengdu, 610072, Sichuan Province, China. wuzhao@med.uestc.edu.cn.

Funding

Fundamental Research Funds for the Central Universities ZYGX2021YGLH216Sichuan Science and Technology Program 2023YFS0092
6 · The paper itself

Abstract

Pulsed electromagnetic field (PEMF) therapy is a potential non-invasive treatment to modulate immune responses and inhibit tumor growth. Cervical cancer (CC) is influenced by IL-37-mediated immune regulation, making PEMF therapy a potential strategy to impede CC progression. This study aimed to elucidate the effects of PEMF on IL-37 regulation and its molecular mechanisms in CC. CC cell-xenografted mouse models, including IL-37 transgenic (IL-37tg) mice, were used to assess tumor growth through in vivo fluorescence imaging and analyze CC cell apoptosis via flow cytometry. TCGA-CESC transcriptome and clinical data were analyzed to identify key inflammation and immune-related genes. CD8

Indexed as

ApoptosisCD8-Positive T-LymphocytesElectromagnetic FieldsInterleukin-1Uterine Cervical NeoplasmsAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleHeLa CellsHumansMagnetic Field TherapyMiceMice, TransgenicOxidative StressIL37 protein, humanInterleukin-1CD8+ T cellsCervical cancerIL-37Pulsed electromagnetic fieldSMAD3/p38/NF-κB signaling pathwayTumor immune microenvironment

Identifiers

PMID39404933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.