Evidence map›Paper›PMID 39404919›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Mortality of alzheimer's disease in Italy from 1980 to 2015.

Daiana Bezzini, Carmelo L Smeralda, Patrizio Pasqualetti, Stefano F Cappa, Lucia Kundisova, Simone Rossi, Monica Ulivelli

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daiana BezziniDepartment of Life Sciences, University of Siena, via Aldo Moro 2, Siena, 53100, SI, Italy. daiana.bezzini@unisi.it.ORCID http://orcid.org/0000-0002-2722-7892
Carmelo L SmeraldaDepartment of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, Policlinico Le Scotte, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0001-5331-9400
Patrizio PasqualettiHealth Statistics, University La Sapienza, Roma, Italy.ORCID http://orcid.org/0000-0001-5560-1979
Stefano F CappaInstitute for Advanced Study, IUSS, Pavia, Italy.ORCID http://orcid.org/0000-0003-1003-3925
Lucia KundisovaPostgradual School of Public Health, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0002-5396-8395
Simone RossiDepartment of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, Policlinico Le Scotte, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0001-6697-9459
Monica UlivelliDepartment of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, Policlinico Le Scotte, University of Siena, Siena, Italy.ORCID http://orcid.org/0000-0003-3463-6341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate mortality for Alzheimer's Disease (AD) in Italy over more than three decades (1980-2015) and discuss the possible role of general and specific contributing factors.

methodsMortality data were extracted by the Italian National Institute of Statistics: crude mortality rates were computed for sex and age, considering the whole country and its five main geographical sub-areas. Rates were standardized in two ways: directly (annual mortality rates AMRs) and indirectly (standardized mortality rates, SMRs). SMRs were then used to evaluate geographical differences; to study mortality trend, AMRs and joinpoint linear regression analysis were used.

resultsConsidering the entire period and the whole country, mortality rates were similar for females and males and for geographical regions, with the exception of the older age groups where mortality for AD in females slightly prevailed. In these older patients, a steep increase of mortality was seen starting from the current century. The increase in male mortality mirrored the national trend in North-West and Central Italy, but not in North-East, South, and the Islands, where it did not surge until the mid to late 1990s.

conclusionsthe general increase of mortality is in line with international data and it reflects the increasing prevalence of the disease, likely due to increasing longevity, and to improvements in diagnostic accuracy. In addition, the accuracy of death certificate compilation could account for both geographical and temporal differences. Currently available drugs for AD do not seem to have an impact on mortality rates.

Indexed as

Alzheimer DiseaseAgedAged, 80 and overAge FactorsFemaleHumansItalyMaleMiddle AgedMortalitySex FactorsAlzheimers’s diseaseDegenerative diseasesEpidemiologyMortality

Identifiers

PMID39404919
PMCPMC11554694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.