Evidence map›Paper›PMID 39404912›Full record

ArticleJournal of materials science. Materials in medicine2024

Tauroursodeoxycholic acid combined with selenium accelerates bone regeneration in ovariectomized rats.

ZhouShan Tao, Min Yang, Cai-Liang Shen

Abstract read
In one paragraph

Article in Journal of materials science. Materials in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

ZhouShan TaoDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, 241001, Anhui, PR China.
Min YangDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, 241001, Anhui, PR China. zhmm5866@126.com.
Cai-Liang ShenDepartment of Spinal Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, PR China.

Funding

Health Research Project of Anhui Province AHWJ2023A20550, AHWJ2023A10149Wuhan Science and Technology Project 2022jc61
6 · The paper itself

Abstract

More recently, increased studies have revealed that antioxidants can cure osteoporosis by inhibiting oxidative stress. Tauroursodeoxycholic acid (TUDCA) and Selenium (Se) have been confirmed to possess potent anti-oxidative effects and accelerate bone regeneration. In addition, very little is currently known about the effects of a combination with Se and TUDCA on bone defects in osteoporotic states. We, therefore, aimed to assess the protective effect of combination with Se and TUDCA on bone regeneration and investigate the effect and underlying mechanisms. When MC3T3-E1 was cultured in the presence of H

Indexed as

Bone RegenerationOvariectomyOxidative StressSeleniumTaurochenodeoxycholic AcidAnimalsAntioxidantsCell LineFemaleMiceOsteoblastsOsteogenesisOsteoporosisRatsRats, Sprague-DawleyReactive Oxygen SpeciesAntioxidantsReactive Oxygen SpeciesSeleniumTaurochenodeoxycholic Acidursodoxicoltaurine

Identifiers

PMID39404912
PMCPMC11480188

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.