Evidence map›Paper›PMID 39404899›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Foveal hyper-reflective vertical lines detected by optical coherence tomography: Imaging features, literature review and differential diagnoses.

Adi Porat Rein, Hashem Totah, Koby Brosh, David Zadok, Joel Hanhart

Abstract readObservational Study
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adi Porat ReinDepartment of Ophthalmology, Shaare Zedek Medical Center, affiliated to the Hebrew University, Shmuel Bait St 12, 9103102, Jerusalem, Israel.
Hashem TotahDepartment of Ophthalmology, Shaare Zedek Medical Center, affiliated to the Hebrew University, Shmuel Bait St 12, 9103102, Jerusalem, Israel.
Koby BroshDepartment of Ophthalmology, Shaare Zedek Medical Center, affiliated to the Hebrew University, Shmuel Bait St 12, 9103102, Jerusalem, Israel.
David ZadokDepartment of Ophthalmology, Shaare Zedek Medical Center, affiliated to the Hebrew University, Shmuel Bait St 12, 9103102, Jerusalem, Israel.
Joel HanhartDepartment of Ophthalmology, Shaare Zedek Medical Center, affiliated to the Hebrew University, Shmuel Bait St 12, 9103102, Jerusalem, Israel. hanhart@szmc.org.il.ORCID http://orcid.org/0000-0003-0952-3740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe foveal hyper-reflective vertical lines (FVL) as a specific morphological finding on structural spectral-domain optical coherence tomography (SD-OCT) and discuss its differential diagnosis.

methodsObservational case series. Ten patients (10 eyes) with FVL were meticulously examined at the Ophthalmology Department, Shaare Zedek Medical Center, Jerusalem, Israel. Detailed analysis of SD-OCT findings, clinical records, and retinal imaging was conducted to establish correlations between FVL and various underlying conditions.

resultsWe established the following list of settings, supported by the clinical context and ancillary investigations, in which SD-OCT displayed FVL: inflammation (1 eye), mechanical (1 eye), resorption of fluids of various origins (4 eyes), macular telangiectasia (1 eye), age-related macular degeneration (1 eye), diabetic retinopathy (1 eye) and scar (1 eye).

conclusionsFVL can be observed in various underlying conditions. Recognition of this pattern and formulation of an appropriate differential diagnosis is of interest for correctly diagnosing and treating patients whose structural OCT harbors this yet overlooked finding.

Indexed as

Fovea CentralisRetinal DiseasesTomography, Optical CoherenceAdultAgedDiagnosis, DifferentialFemaleFluorescein AngiographyHumansMaleMiddle AgedRetrospective StudiesVisual AcuityFoveaHyper-reflectivityMacular edemaOCT

Identifiers

PMID39404899
PMCPMC11953122

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.