Evidence map›Paper›PMID 39404893›Full record

ArticleActa neurochirurgica2024

Analyzing the safety and efficacy of pipeline embolization device in pediatric aneurysms: insight from a mul-ticenter cohort and pooled analysis.

Yang Zhao, Junlin Lu, Zhipeng Li, Xiaolin Chen, Xinjian Yang, Yuanli Zhao, Shuo Wang, Qiang Hao

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yang ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Junlin LuDepartment of Neurosurgery, West China Hospital, Sichuan University, Sichuan, China.
Zhipeng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xiaolin ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xinjian YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yuanli ZhaoDepartment of Neurosurgery, Peking Union Medical College Hospital, Beijing, China.
Shuo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. captain9858@126.com.
Qiang HaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. haoqiang713@163.com.

Funding

1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University 2023HXBH116Beijing Municipal Administration of Hospitals pX2020023Beijing Municipal Natural Science Foundation 7204253National Key Research and Development Program of China 2021YFC2501101National Key Research and Development Program of China 2022YFB4702800Peking University International Hospital Research Grant YN2023QN08
6 · The paper itself

Abstract

backgroundPediatric patients with intracranial aneurysms face high risks of spontaneous subarachnoid hemorrhages. Despite its approval for adults aged 22 and above, the Pipeline Embolization Device (PED, Covidien/Medtronic, Irvine, California, USA) is being considered for younger patients due to its efficacy. This study aims to assess the safety and effectiveness of using PEDs in pediatric aneurysm treatment.

methodsA retrospective study across 14 institutions identified 25 patients (age ≤ 18) treated with PED from November 2014 to October 2019. A literature review included all published pediatric aneurysm cases treated with PED from 2007 to 2023. Analyzed data included patient demographics, aneurysm characteristics, treatment, clinical outcomes, and complications.

resultsWe analyzed 81 pediatric patients, including 25 from the multi-center registry and 56 from 38 relevant literature. In the entire cohort of 81 patients, mean age of the patients was 11.9 ± 4.0 years (ranged from 9 months to 18 years), with 58.0% males. Ruptured aneurysms were observed in 7 patients (8.6%), whereas 43 patients (53.1%) harbored large/giant aneurysms. The aneurysm occlusion rate was 87.7% during the median 7 months follow-up. Complications occurred in 12.3% of patients, resulting in morbidity in 5 cases (6.1%) and mortality in 4 cases (4.9%). Patient age was not associated with the occurrence of aneurysm residual, complications, and mortality following PED treatment.

conclusionsPED can be effective for pediatric aneurysms, but morbidity and mortality can be substantial compared to the adults. Surgical timing should depend on clinical judgment and patient factors, without age-related delays.

Indexed as

Embolization, TherapeuticIntracranial AneurysmAdolescentAneurysm, RupturedChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleRetrospective StudiesTreatment OutcomeAneurysmPediatricsPipeline embolization deviceStroke

Identifiers

PMID39404893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.