Evidence map›Paper›PMID 39404632›Full record

ArticleRadiology2024

Prediction of Ischemic Stroke Functional Outcomes from Acute-Phase Noncontrast CT and Clinical Information.

Yongkai Liu, Yannan Yu, Jiahong Ouyang, Bin Jiang, Sophie Ostmeier, Jia Wang, Sarah Lu-Liang, Yirong Yang, Guang Yang, Patrik Michel and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yongkai LiuFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0003-4478-4006
Yannan YuFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-1718-6505
Jiahong OuyangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-0434-5757
Bin JiangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-8507-0459
Sophie OstmeierFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0003-3097-7042
Jia WangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0003-3295-5963
Sarah Lu-LiangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0009-0006-5560-6140
Yirong YangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0009-0002-5999-6271
Guang YangFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0001-7344-7733
Patrik MichelFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).
David S LiebeskindFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).
Maarten LansbergFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-3545-6927
Michael E MoseleyFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-9163-8741
Jeremy J HeitFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-1058-1393
Max WintermarkFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0002-6726-3951
Gregory AlbersFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0003-0263-4632
Greg ZaharchukFrom the Departments of Radiology (Y.L., J.O., B.J., S.O., Y. Yang, M.E.M., J.J.H., G.Z.) and Neurology (M.L., G.A.), Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA 94305-5488; Department of Radiology, University of California-San Francisco, San Francisco, Calif (Y. Yu); Department of Electrical Engineering (J.O.) and Department of Environmental Health and Safety (J.W.), Stanford University, Stanford, Calif; Henry M. Gunn Senior High School, Palo Alto, Calif (S.L.L.); National Heart and Lung Institute, Imperial College London, London, UK (G.Y.); Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland (P.M.); Department of Neurology, University of California Los Angeles, Los Angeles, Calif (D.S.L.); and Department of Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.W.).ORCID 0000-0001-5781-8848

Funding

PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)R01NS121720 · NINDS · STANFORD UNIVERSITY · PI GREGORY W ALBERS, Jeremy J Heit · 2021 to 2026
$7.0M
Predicting Tissue and Functional Outcome in Acute StrokeR01NS130172 · NINDS · STANFORD UNIVERSITY · PI Gregory George Zaharchuk · 2023 to 2026
$2.4M
NINDS NIH HHS R01 NS121720NINDS NIH HHS R01 NS130172
6 · The paper itself

Abstract

Background Clinical outcome prediction based on acute-phase ischemic stroke data is valuable for planning health care resources, designing clinical trials, and setting patient expectations. Existing methods require individualized features and often involve manually engineered, time-consuming postprocessing activities. Purpose To predict the 90-day modified Rankin Scale (mRS) score with a deep learning (DL) model fusing noncontrast-enhanced CT (NCCT) and clinical information from the acute phase of stroke. Materials and Methods This retrospective study included data from six patient datasets from four multicenter trials and two registries. The DL-based imaging and clinical model was trained by using NCCT data obtained 1-7 days after baseline imaging and clinical data (age; sex; baseline and 24-hour National Institutes of Health Stroke Scale scores; and history of hypertension, diabetes, and atrial fibrillation). This model was compared with models based on either NCCT or clinical information alone. Model-specific mRS score prediction accuracy, mRS score accuracy within 1 point of the actual mRS score, mean absolute error (MAE), and performance in identifying unfavorable outcomes (mRS score, >2) were evaluated. Results A total of 1335 patients (median age, 71 years; IQR, 60-80 years; 674 female patients) were included for model development and testing through sixfold cross validation, with distributions of 979, 133, and 223 patients across training, validation, and test sets in each of the six cross-validation folds, respectively. The fused model achieved an MAE of 0.94 (95% CI: 0.89, 0.98) for predicting the specific mRS score, outperforming the imaging-only (MAE, 1.10; 95% CI: 1.05, 1.16;

Indexed as

Deep LearningIschemic StrokeTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective Studies

Identifiers

PMID39404632
PMCPMC11535867

What OpenQuestion holds

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Registered trials

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