Evidence map›Paper›PMID 39404464›Full record

ReviewDrug delivery2024

Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics.

Shan Li, Tianyu Wu, Jingfeng Wu, Wensheng Chen, Dinglin Zhang

Abstract readReview
In one paragraph

Review in Drug delivery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shan LiDepartment of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
Tianyu WuDepartment of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Jingfeng WuDepartment of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Wensheng ChenDepartment of Gastroenterology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Dinglin ZhangDepartment of Chemistry, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, China.ORCID 0000-0003-4400-919X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gastrointestinal tract (GIT) is an important and complex system by which humans to digest food and absorb nutrients. The GIT is vulnerable to diseases, which may led to discomfort or even death in humans. Therapeutics for GIT disease treatment face multiple biological barriers, which significantly decrease the efficacy of therapeutics. Recognizing the biological barriers and pathophysiological characteristics of GIT may be helpful to design innovative therapeutics. Nanotherapeutics, which have special targeting and controlled therapeutic release profiles, have been widely used for the treatment of GIT diseases. Herein, we provide a comprehensive review of the biological barrier and pathophysiological characteristics of GIT, which may aid in the design of promising nanotherapeutics for GIT disease treatment. Furthermore, several typical diseases of the upper and lower digestive tracts, such as

Indexed as

Gastrointestinal TractNanoparticlesAnimalsDrug Delivery SystemsGastrointestinal DiseasesHumansgastrointestinal tractHelicobacter pylori infectioninflammatory bowel diseaseNanotherapeutics

Identifiers

PMID39404464
PMCPMC11485891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.