Evidence map›Paper›PMID 39404393›Full record

ArticleCells2024

Role of WISP1 in Stellate Cell Migration and Liver Fibrosis.

Daniela González, Gisela Campos, Larissa Pütter, Adrian Friebel, Christian H Holland, Leonhard Holländer, Ahmed Ghallab, Zaynab Hobloss, Maiju Myllys, Stefan Hoehme and 6 more

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniela GonzálezIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.ORCID 0000-0002-0092-1411
Gisela CamposIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Larissa PütterIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Adrian FriebelInterdisciplinary Centre for Bioinformatics (IZBI) & Saxonian Incubator for Clinical Research (SIKT), University of Leipzig, Haertelstraße 16-18, 04107 Leipzig, Germany.
Christian H HollandIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.ORCID 0000-0002-3060-5786
Leonhard HolländerIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Ahmed GhallabIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.ORCID 0000-0003-0695-3403
Zaynab HoblossIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Maiju MyllysIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.ORCID 0000-0001-9117-4572
Stefan HoehmeInterdisciplinary Centre for Bioinformatics (IZBI) & Saxonian Incubator for Clinical Research (SIKT), University of Leipzig, Haertelstraße 16-18, 04107 Leipzig, Germany.ORCID 0000-0002-9716-9587
Nadja M Meindl-BeinkerDepartment of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, Germany.ORCID 0000-0003-0211-352X
Steven DooleyDepartment of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, Germany.ORCID 0000-0002-4840-6240
Rosemarie MarchanIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Thomas S WeissChildren's University Hospital (KUNO), University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0003-0336-0581
Jan G HengstlerIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.
Patricio GodoyIfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany.

Funding

Deutsche Forschungsgemeinschaft; Federal Ministry of Education and Research DFG GO 1987/2-1 and DFG GO 1987/1-1; 031L0257D
6 · The paper itself

Abstract

The mechanisms underlying the remarkable capacity of the liver to regenerate are still not completely understood. Particularly, the cross-talk between cytokines and cellular components of the process is of utmost importance because they represent potential avenues for diagnostics and therapeutics. WNT1-inducible-signaling pathway protein 1 (WISP1) is a cytokine member of the CCN family, a family of proteins that play many different roles in liver pathophysiology. WISP1 also belongs to the earliest and strongest upregulated genes in mouse livers after CCl

Indexed as

CCN Intercellular Signaling ProteinsCell MovementHepatic Stellate CellsLiver CirrhosisMice, KnockoutProto-Oncogene ProteinsTransforming Growth Factor betaAnimalsHumansLiverMaleMiceMice, Inbred C57BLCCN4 protein, mouseCCN Intercellular Signaling ProteinsProto-Oncogene ProteinsTransforming Growth Factor betacollagenliver fibrosisstellate cellsWISP1

Identifiers

PMID39404393
PMCPMC11475959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.