Evidence map›Paper›PMID 39404366›Full record

ArticleCells2024

The Systemic Effect of Ischemia Training and Its Impact on Bone Marrow-Derived Monocytes.

Gustavo Falero-Diaz, Catarina de A Barboza, Katherine Kaiser, Keri A Tallman, Christopher Montoya, Shailendra B Patel, Joshua D Hutcheson, Roberta M Lassance-Soares

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gustavo Falero-DiazDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0009-0008-0503-3713
Catarina de A BarbozaDepartment of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Katherine KaiserDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
Keri A TallmanDepartment of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0001-7331-2601
Christopher MontoyaDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Shailendra B PatelDepartment of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Cincinnati, Cincinnati, OH 45221, USA.
Joshua D HutchesonDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
Roberta M Lassance-SoaresDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-0509-2616

Funding

C-KIT SIGNALING IN COLLATERALS REMODELINGK01HL145359 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LASSANCE-SOARES, ROBERTA MARQUES · 2019 to 2023
$632k
NIH HHS 1K01HL145359
6 · The paper itself

Abstract

objectiveMonocytes are innate immune cells that play a central role in inflammation, an essential component during neovascularization. Our recent publication demonstrated that ischemia training by 24 h unilateral occlusion of the femoral artery (FA) can modify bone marrow-derived monocytes (BM-Mono), allowing them to improve collateral remodeling in a mouse model of hindlimb ischemia. Here, we expand on our previous findings, investigating a potential systemic effect of ischemia training and how this training can impact BM-Mono. METHODS AND

resultsBM-Mono from mice exposed to ischemia training (24 h) or Sham (same surgical procedure without femoral artery occlusion-ischemia training) procedures were used as donors in adoptive transfer experiments where recipients were subjected to hindlimb ischemia. Donor cells were divided corresponding to the limb from which they were isolated (left-limb previously subjected to 24 h ischemia and right-contralateral limb). Recipients who received 24 h ischemic-trained monocytes isolated from either limb had remarkable blood flow recovery compared to recipients with Sham monocytes (monocytes isolated from Sham group-no ischemia training). Since these data suggested a systemic effect of ischemic training, circulating extracellular vesicles (EVs) were investigated as potential players. EVs were isolated from both groups, 24 h-trained and Sham, and the former showed increased expression of histone deacetylase 1 (

conclusionsIschemia training leads to a systemic effect that, at least in part, involves circulating EVs and potential epigenetic modification in BM-Mono. These ischemic-trained BM-Mono demonstrated an anti-inflammatory phenotype towards M2 macrophage differentiation and less ability to adhere to endothelial cells, which is associated with the downregulation of

Indexed as

IschemiaMonocytesAnimalsBone Marrow CellsHindlimbMaleMiceMice, Inbred C57BLPhysical Conditioning, Animalextracellular vesicleshindlimb ischemiainflammationischemia trainingmonocytessystemic effect

Identifiers

PMID39404366
PMCPMC11475150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.