Evidence map›Paper›PMID 39404363›Full record

ArticleCells2024

Lumican/Lumikine Promotes Healing of Corneal Epithelium Debridement by Upregulation of EGFR Ligand Expression via Noncanonical Smad-Independent TGFβ/TBRs Signaling.

Winston W Y Kao, Jianhua Zhang, Jhuwala Venkatakrishnan, Shao-Hsuan Chang, Yong Yuan, Osamu Yamanaka, Ying Xia, Tarsis F Gesteira, Sudhir Verma, Vivien J Coulson-Thomas and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Winston W Y KaoDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-8502-0531
Jianhua ZhangDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.
Jhuwala VenkatakrishnanDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.
Shao-Hsuan ChangDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0003-4136-7928
Yong YuanDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.
Osamu YamanakaDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.
Ying XiaDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.
Tarsis F GesteiraCollege of Optometry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-0136-0986
Sudhir VermaCollege of Optometry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-2891-1987
Vivien J Coulson-ThomasCollege of Optometry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-5848-0225
Chia-Yang LiuDepartment of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267, USA.

Funding

Gene Therapy of Corneal Dystrophy: Lysosomal Storage DiseasesR01EY029427 · NEI · UNIVERSITY OF CINCINNATI · PI KAO, WINSTON W · 2019 to 2021
$1.2M
NEI NIH HHS R01 EY029427
6 · The paper itself

Abstract

The synthetic peptide of lumican C-terminal 13 amino acids with the cysteine replaced by an alanine, hereafter referred to as lumikine (LumC13

Indexed as

Epithelium, CornealErbB ReceptorsLumicanSignal TransductionSmad ProteinsTransforming Growth Factor betaWound HealingAnimalsDebridementHumansLigandsMiceMice, Inbred C57BLMice, KnockoutReceptor, Transforming Growth Factor-beta Type IUp-RegulationErbB ReceptorsLigandsLumicanLum protein, mouseReceptor, Transforming Growth Factor-beta Type ISmad ProteinsTgfbr1 protein, mouseTransforming Growth Factor betacorneaEGFREGFR ligandsepithelium debridementlumicanlumikineTGFβ signaling pathwayswound healing

Identifiers

PMID39404363
PMCPMC11475839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.