Interaction of 6-Thioguanine with Aluminum Metal-Organic Framework Assisted by Mechano-Chemistry, In Vitro Delayed Drug Release, and Time-Dependent Toxicity to Leukemia Cells.

Sheriff Umar, Xavier Welch, Chihurumanya Obichere, Brandon Carter-Cooper, Alexander Samokhvalov

Abstract read

In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheriff UmarDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA.ORCID 0000-0003-4407-635X

Xavier WelchDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA.

Chihurumanya ObichereDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA.ORCID 0000-0002-7041-6154

Brandon Carter-CooperTranslational Laboratory Shared Services (TLSS), The University of Maryland School of Medicine's & Greenebaum Comprehensive Cancer Center, 22 S. Greene Street, Baltimore, MD 21201, USA.

Alexander SamokhvalovDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA.ORCID 0000-0002-7273-7322

Funding

Project-002UL1GM118973 · NIGMS · MORGAN STATE UNIVERSITY · PI KAMANGAR, FARIN · 2015 to 2023

$18.8M

NIGMS NIH HHS UL1 GM118973NIGMS NIH HHS UL1GM118973

6 · The paper itself

Abstract

6-thioguanine (6-TG) is an antimetabolite drug of purine structure, approved by the FDA for the treatment of acute myeloid lesukemia, and it is of interest in treating other diseases. The interaction of drugs with matrices is of interest to achieving a delayed, sustained, and local release. The interaction of 6-TG with an aluminum metal-organic framework (Al-MOF) DUT-4 is studied using a novel experimental approach, namely, mechano-chemistry by liquid-assisted grinding (LAG). The bonding of 6-TG to the DUT-4 matrix in the composite (6-TG)(DUT-4) was studied using ATR-FTIR spectroscopy and XRD. This interaction involves amino groups and C and N atoms of the heterocyclic ring of 6-TG, as well as the carboxylate COO

Indexed as

6-thioguaninecancerdelayed drug releaseleukemiamechano-chemistrymetal–organic framework

Identifiers

PMID39404299

DOI10.3390/nano14191571

PMCPMC11477990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.